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Pearl Toh, 20 Nov 2019
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Genetic susceptibility influences weight-loss mediated BP reduction

6 days ago

Genetic predisposition to elevated blood pressure (BP) may affect BP changes in response to weight-loss diets, such that individuals with higher genetic susceptibility exhibit less decrease in BP levels, a study has found. Moreover, this effect differs by protein intake.

Researchers evaluated the changes in systolic and diastolic BP (SBP/DBP) among 692 overweight or obese adults (mean age, 51.4 years; 61.1 percent female; mean body mass index [BMI], 32.7 kg/m2; 84.2 percent Whites) who were randomly assigned to one of four diets varying in macronutrient content for 2 years.

Participants were grouped according to polygenic scores (PGS) for SBP and DBP calculated based on BP-associated single nucleotide polymorphisms.

During the 2-year intervention, the reductions observed in SBP levels were significantly greater for participants in the bottom vs upper tertile of PGS (6 months: −3.84 vs −1.61; 12 months: −4.76 vs −2.75; 24 months: 2.49 vs 1.63; p=0.001). The same was observed for changes in DBP levels (6 months: −3.09 vs −1.34; 12 months: −2.69 vs −1.44; 24 months: 1.82 vs 0.53; p<0.001).

There was a notable gene–diet interaction on changes in SBP from baseline to 24 months (p-interaction=0.009). In the group of participants assigned to a high-protein diet, those with lower SBP-PGS achieved greater decreases in SBP at months 6 (p=0.018), 12 (p=0.007) and 24 (p=0.089). No such effect was seen in the group of participants assigned to an average-protein diet.

The present data support a personalized diet approach in preventing hypertension, according to the researchers. Overweight and obese individuals with a lower SBP-PGS should see greater weight-loss mediated BP reduction and may benefit even more from consuming a high-protein weight-loss diet.

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Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
3 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.