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Genetic polymorphisms predict psoriasis vulgaris response to methotrexate

11 Feb 2019
Passing down of bipolar disorder genes is also a factor in increasing suicide risk among adolescents.

Single nucleotide polymorphisms (SNPs) in the SMG6, IMMT and UPK1A genes affect the efficacy of methotrexate in patients with psoriasis vulgaris, a new study has shown.

Whole-exon high-throughput sequencing technology was used to assess the DNA of 22 psoriasis vulgaris patients, half of whom were nonresponders (mean age 44±13 years; 50 percent male; responders: mean age 48±15 years; 50 percent male) to methotrexate. Medication response was defined as a decrease in the Psoriasis Area and Severity Index >75 percent.

Fifty SNPs were selected for further validation by the MassARRAY method. Of these, 36 putative SNPs were identified in the present study, while the remaining 14 had been previously reported in the literature. After selecting for SNPs with a frequency >5 percent, genotyping rate ≥95 percent, and which satisfied the Hardy-Weinberg equilibrium, 42 remained qualified for further analysis.

On multivariate logistic regression analysis, three SNPs achieved statistical significance. The rs216195 GT (odds ratio [OR], 5.574; 95 percent CI, 1.1035–30.032; p=0.046) and GG (OR, 6.174; 1.114–33.922; p=0.037) genotypes of the SMG6 gene were all significantly associated with an effective response relative to the TT genotype.

For the IMMT gene, the rs1050301 AA (OR, 0.246; 0.061–0.0990; p=0.049) genotype was correlated with a poorer response relative to the GG phenotype. The rs2285421 TC (OR, 4.420; 1.175–16.630; p=0.028) and CC (OR, 2.795; 0.689–11.331; p=0.029) genotypes of the UPK1A gene were associated with a better response relative to the TT genotype.

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Most Read Articles
4 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
2 days ago
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
17 Aug 2019
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
6 days ago
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.