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Genetic polymorphisms predict psoriasis vulgaris response to methotrexate

11 Feb 2019
Passing down of bipolar disorder genes is also a factor in increasing suicide risk among adolescents.

Single nucleotide polymorphisms (SNPs) in the SMG6, IMMT and UPK1A genes affect the efficacy of methotrexate in patients with psoriasis vulgaris, a new study has shown.

Whole-exon high-throughput sequencing technology was used to assess the DNA of 22 psoriasis vulgaris patients, half of whom were nonresponders (mean age 44±13 years; 50 percent male; responders: mean age 48±15 years; 50 percent male) to methotrexate. Medication response was defined as a decrease in the Psoriasis Area and Severity Index >75 percent.

Fifty SNPs were selected for further validation by the MassARRAY method. Of these, 36 putative SNPs were identified in the present study, while the remaining 14 had been previously reported in the literature. After selecting for SNPs with a frequency >5 percent, genotyping rate ≥95 percent, and which satisfied the Hardy-Weinberg equilibrium, 42 remained qualified for further analysis.

On multivariate logistic regression analysis, three SNPs achieved statistical significance. The rs216195 GT (odds ratio [OR], 5.574; 95 percent CI, 1.1035–30.032; p=0.046) and GG (OR, 6.174; 1.114–33.922; p=0.037) genotypes of the SMG6 gene were all significantly associated with an effective response relative to the TT genotype.

For the IMMT gene, the rs1050301 AA (OR, 0.246; 0.061–0.0990; p=0.049) genotype was correlated with a poorer response relative to the GG phenotype. The rs2285421 TC (OR, 4.420; 1.175–16.630; p=0.028) and CC (OR, 2.795; 0.689–11.331; p=0.029) genotypes of the UPK1A gene were associated with a better response relative to the TT genotype.

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Most Read Articles
5 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
6 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, 4 days ago
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.
12 Apr 2019
Acetaminophen remains a safe choice of analgesic for most elderly residents of nursing homes, a recent study suggests.