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Genetic polymorphisms predict psoriasis vulgaris response to methotrexate

11 Feb 2019
Passing down of bipolar disorder genes is also a factor in increasing suicide risk among adolescents.

Single nucleotide polymorphisms (SNPs) in the SMG6, IMMT and UPK1A genes affect the efficacy of methotrexate in patients with psoriasis vulgaris, a new study has shown.

Whole-exon high-throughput sequencing technology was used to assess the DNA of 22 psoriasis vulgaris patients, half of whom were nonresponders (mean age 44±13 years; 50 percent male; responders: mean age 48±15 years; 50 percent male) to methotrexate. Medication response was defined as a decrease in the Psoriasis Area and Severity Index >75 percent.

Fifty SNPs were selected for further validation by the MassARRAY method. Of these, 36 putative SNPs were identified in the present study, while the remaining 14 had been previously reported in the literature. After selecting for SNPs with a frequency >5 percent, genotyping rate ≥95 percent, and which satisfied the Hardy-Weinberg equilibrium, 42 remained qualified for further analysis.

On multivariate logistic regression analysis, three SNPs achieved statistical significance. The rs216195 GT (odds ratio [OR], 5.574; 95 percent CI, 1.1035–30.032; p=0.046) and GG (OR, 6.174; 1.114–33.922; p=0.037) genotypes of the SMG6 gene were all significantly associated with an effective response relative to the TT genotype.

For the IMMT gene, the rs1050301 AA (OR, 0.246; 0.061–0.0990; p=0.049) genotype was correlated with a poorer response relative to the GG phenotype. The rs2285421 TC (OR, 4.420; 1.175–16.630; p=0.028) and CC (OR, 2.795; 0.689–11.331; p=0.029) genotypes of the UPK1A gene were associated with a better response relative to the TT genotype.

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Most Read Articles
Roshini Claire Anthony, 2 days ago

A subgroup of patients with HBeAg-negative chronic hepatitis B virus (HBV) infection who ceased their long-term nucleotide analogue treatment maintained virological suppression, pointing to a group of patients who may be suitable for treatment cessation, according to a recent study.

Rachel Soon, 4 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

3 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 6 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.