Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Gene score predicts prostate cancer risk

18 Jan 2018

A polygenic hazard score appears to accurately estimate genetic risk and predict age at onset of aggressive prostate cancer, a recent study shows.

Using single nucleotide polymorphisms of 31,747 males, the researchers developed a polygenic hazard score to assess individual prostate cancer genetic risk and applied it to a cohort of 6,411 males. The main outcome was the predictive accuracy for age of onset of aggressive malignancy in the validation cohort.

According to a Cox proportional hazards model, the polygenic hazard score showed significant predictive ability for the age of onset of aggressive prostate cancer (z=11.2; p<10-16), any prostate cancer (z=15.4; p<10-16) and very aggressive prostate cancer (z=6.8; p<10-11).

Those in the >98th percentile of polygenic hazard scores were identified as high-risk patients and showed significantly higher risks of any prostate cancer (hazard ratio [HR], 2.5; 95 percent CI, 2.2–2.8), aggressive disease (HR, 3.0; 2.2–4.0) and early age of onset (HR, 2.9; 2.4–3.4).

A model developed using only aggressive prostate cancer cases also showed significant predictive value but did not outperform the original model (z=9.4; p<10-16; HR, 2.6; 2.1–3.1).

In a subsequent Cox test performed on patients with known family history statuses, there was no correlation between age of onset of aggressive disease and family history (z=0.9; p=0.37; HR, 1.1; 0.9–1.4).

Inclusion of family history in the model did not improve the predictive value over the original polygenic hazard score for any prostate cancer (p=0.14) or aggressive prostate cancer (p=0.59).

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Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.