Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

2 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
12 Apr 2019
Long-acting beta2-agonist (LABA) plus long-acting muscarinic antagonist (LAMA) combinations compare with inhalers containing both LABA and corticosteroid (LABA-ICS) in terms of reducing chronic obstructive pulmonary disease (COPD) exacerbations, although the LAMA-LABA combination is more favourable as it is associated with fewer episodes of severe pneumonia, according to a study.
3 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.

Gene score predicts prostate cancer risk

18 Jan 2018

A polygenic hazard score appears to accurately estimate genetic risk and predict age at onset of aggressive prostate cancer, a recent study shows.

Using single nucleotide polymorphisms of 31,747 males, the researchers developed a polygenic hazard score to assess individual prostate cancer genetic risk and applied it to a cohort of 6,411 males. The main outcome was the predictive accuracy for age of onset of aggressive malignancy in the validation cohort.

According to a Cox proportional hazards model, the polygenic hazard score showed significant predictive ability for the age of onset of aggressive prostate cancer (z=11.2; p<10-16), any prostate cancer (z=15.4; p<10-16) and very aggressive prostate cancer (z=6.8; p<10-11).

Those in the >98th percentile of polygenic hazard scores were identified as high-risk patients and showed significantly higher risks of any prostate cancer (hazard ratio [HR], 2.5; 95 percent CI, 2.2–2.8), aggressive disease (HR, 3.0; 2.2–4.0) and early age of onset (HR, 2.9; 2.4–3.4).

A model developed using only aggressive prostate cancer cases also showed significant predictive value but did not outperform the original model (z=9.4; p<10-16; HR, 2.6; 2.1–3.1).

In a subsequent Cox test performed on patients with known family history statuses, there was no correlation between age of onset of aggressive disease and family history (z=0.9; p=0.37; HR, 1.1; 0.9–1.4).

Inclusion of family history in the model did not improve the predictive value over the original polygenic hazard score for any prostate cancer (p=0.14) or aggressive prostate cancer (p=0.59).

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Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

2 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
12 Apr 2019
Long-acting beta2-agonist (LABA) plus long-acting muscarinic antagonist (LAMA) combinations compare with inhalers containing both LABA and corticosteroid (LABA-ICS) in terms of reducing chronic obstructive pulmonary disease (COPD) exacerbations, although the LAMA-LABA combination is more favourable as it is associated with fewer episodes of severe pneumonia, according to a study.
3 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.