Most Read Articles
Pearl Toh, 6 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Gastrointestinal bleeding tied to poorer outcomes in STEMI patients

18 Jul 2019

While gastrointestinal bleeding (GIB) is uncommon among patients with ST-elevation myocardial infarction (STEMI), the complication leads to greater morbidity, mortality and resource utilization, reports a new study.

The study included 1,450,696 STEMI patients, of which only 2.2 percent (n=32,624) were complicated with GIB. The incidence rate of GIB in STEMI decreased over time, going from 2.7 percent in the year 2003 to 2.0 percent in 2016 (p-trend<0.001). Those with GIB were older (73±14 vs 68±15 years; p<0.001) and were more likely to be female (44.9 percent vs 36.8 percent; p<0.001).

Compared with patients who did not develop the complication, those with GIB had significantly higher incidence rates of in-hospital mortality (28.2 percent vs 11.1 percent; p<0.001), acute kidney injury (29.8 percent vs 11.0 percent; p<0.001) and stroke (3.5 percent vs 1.5 percent; p<0.001).

In addition, patients with GIB were also more likely to need blood transfusion (29.3 percent vs 5.8 percent; p<0.001) and new dialysis requirements (2.5 percent vs 0.7 percent; p<0.001), and were less likely to be discharged from the hospital (nondischarge: 41.5 percent vs 25.8 percent; p<0.001).

Median length of stay (6 vs 3 days; p<0.001) as well as mean cost (USD 30,752±42,802 vs 21,372±23,552; p<0.001) were similarly significantly higher in patients who developed GIB.

“To our knowledge, this is the largest nationwide analysis examining the incidence and outcomes of GIB in patients admitted with STEMI,” said researchers. “[W]e believe that this study offers important insights into a high-risk cohort of patients in whom data to guide optimal therapy are scarce.”

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Most Read Articles
Pearl Toh, 6 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.