Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

16 Aug 2014

New drug applications approved by US FDA as of 15-30 Aug which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.

Gamma Knife radiosurgery safe for hypothalamic hamartoma

13 Jul 2017
The medical community will be strictly observed following this incident.

Gamma Knife (GK) radiosurgery is a safe approach to hypothalamic hamartoma, a new study reveals. Specifically, there are no major endocrine side effects observed.

GK, with a mean dose of 17.1±2.3 Gy, was delivered to 34 patients with mean age at surgery of 18.2±11.1 years. The mean BMI of the cohort was 25.1±2.8 kg/m2. GK was a first-line treatment in 32 patients while the remaining two had undergone prior surgeries. The mean time to follow-up after surgery was 3.6±2 years.

One patient experienced a weight gain of around 10 kg following GK surgery; by final evaluation, weight had returned to a level comparable to baseline. Mean BMI after GK surgery was 26.9 kg/m2, and no significant difference in pre- and post-GK BMI was calculated (p=0.59).

There was one case of new pituitary deficiency: thyroid stimulating hormone deficiency diagnosed 2 years after GK surgery and which persisted until 5 years after the procedure.

Two patients had deficiencies in luteinizing hormone (LH)/follicle-stimulating hormone (FSH) levels at baseline and showed no unusual significant changes over the course of the study. No other gonadotroph deficiencies were detected.

Similar to baseline, there were no documented deficiencies in adenocorticotropin hormone (ACTH) and growth hormone (GH). No abnormal changes in prolactin, sodium and diuresis were observed.

Participants with hypothalamic hamartoma and who had endocrinologic follow-up of at least 2 years after treatment were included. Evaluations were at 3 months and 2 years after GK. Among the information retrieved from records were radiosurgical parameters, hamartoma characteristics, anthropometric measurements and endocrinologic evaluation results.

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Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

16 Aug 2014

New drug applications approved by US FDA as of 15-30 Aug which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.