Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Galectin-3 may predict cognitive decline in T2DM

23 Apr 2020

In patients with type 2 diabetes mellitus (T2DM), galectin-3 (gal3) levels may be an indicator of mild cognitive impairment (MCI), a new study has shown.

In a sample of 134 hospitalized T2DM patients, 65 (mean age, 69.62±6.53 years; 46.2 percent female) had MCI, which was assessed using the Montreal Cognitive Assessment (MoCA) tool. The remaining 69 (mean age, 68.35±5.62 years; 46.4 percent female) were set as controls. Fasting blood samples were collected and processed through enzyme-linked immunosorbent assays (ELISA) for the measurement of gal3.

In the MCI group, MoCA scores were significantly but negatively correlated with gal3 levels (r, –0.47; p<0.001). The same was true for results in the Mini Mental State Examination (MMSE; r, –0,51, p<0.01). Other significant negative predictors of both measures were glycated haemoglobin (HbA1c) and the homeostasis model assessment of insulin resistance (HOMA-IR).

In contrast, both MoCA and MMSE scores of the MCI patients were positively correlated with amyloid-β42 in the plasma. Blood biomarkers were unrelated to MoCA scores in controls.

Simple logistic regression confirmed that gal3 was a significant and independent risk factor for developing MCI in T2DM patients (odds ratio [OR], 5.45, 95 percent confidence interval [CI], 2.10–6.64), as was amyloid-β42 concentration (OR, 1.76, 95 percent CI, 1.27–1.94).

“We recommend large-scale multicentre studies to assess the clinical application of Gal3 as an independently novel biomarker for MCI T2DM patients,” said researchers. “Whether Gal3 is simply a disease biomarker or is also a mediator of the development and progression of diabetic cognitive impairment warrants further investigation.”

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Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.