Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
3 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Pearl Toh, 3 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
3 days ago
While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.

Gait problems may be an early indicator of cognitive decline, dementia

26 Oct 2019

Impaired quantitative gait precedes cognitive decline and may be a useful indicator for the eventual development of dementia, a recent study has found.

The study included 4,258 participants (median age, 67 years; 55 percent female) who were free of dementia at baseline. Quantitative gait was measured through the GAITRite system, while cognitive assessments were performed using the Stroop colour word test, Letter Digit Substitution Test, Word Fluency Test, 15-Word List Learning Test and Purdue Pegboard Test.

A summary of seven mutually independent gait domains was used for the analysis. Researchers found that baseline impairments in the domains of pace (β, 0.06, 95 percent CI, 0.04–0.09; p<0.001), base of support (β, 0.03, 0.01–0.05; p=0.003) and rhythm (β, 0.02. 0.00–0.04; p=0.02) were significantly correlated with a decline in global cognition.

In particular, pace was associated with a decline in all cognitive tests except for the World Learning Test recognition task. Base of support, on the other hand, was tied to Stroop interference and naming tasks, while rhythm correlated with scores in the Stroop interference task and Word Fluency Test.

Global gait scores were likewise significantly associated with a deterioration of global cognition (β, 0.06, 0.03–0.08; p<0.001).

Over a median follow-up of 4 years, 78 cases of incident dementia were recorded, most of whom (82 percent; n=64) had Alzheimer’s disease. Gait pace (hazard ratio [HR], 1.33, 1.04–1.71; p=0.02) and variability (HR, 1.25, 1.01–1.56; p=0.04) emerged as significant risk factors.

Moreover, each standard-deviation decrease in the global gait score corresponded to a 29-percent increase in the likelihood of incident dementia (HR, 1.29, 1.08–1.54; p=0.006).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
3 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Pearl Toh, 3 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
3 days ago
While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.