Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.

Gabapentin useful as alternative treatment for vasomotor symptoms

15 Mar 2020

Gabapentin is beneficial in the treatment of vasomotor symptoms in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives, according to the results of a systematic review and meta-analysis.

Researchers searched multiple online databases for relevant studies evaluating the efficacy of gabapentin in terms of the following: frequency, duration and composite score of hot flushes (primary outcomes), and adverse effects and dropout rate (secondary outcomes).

Standardized mean difference (SMD) and combined odds ratio (OR) were estimated using fixed or random-effects models, depending on study heterogeneity. Additional subgroup and meta-regression analyses of gabapentin dosage were carried out.

The meta-analysis included seven randomized controlled trials that assessed single-agent gabapentin vs placebo in postmenopausal women with hot flushes. Pooled data showed that the active drug conferred superior improvements in terms of the frequency (SMD, 2.99, 95 percent confidence interval [CI], 2.01–3.98; p<0.001), duration (SMD, 0.89, 95 percent CI, 0.49–1.30; p<0.001) and composite score (SMD, 2.31, 95 percent CI, 1.50–3.11; p<0.001) of hot flushes.

Adverse events occurred with greater frequency among gabapentin-treated women than among those taking placebo, specifically dizziness (OR, 1.58, 95 percent CI, 0.98–2.18; p<0.001) and unsteadiness (OR, 1.19, 95 percent CI, 0.43–1.95; p=0.002).

The present data show that gabapentin may be used to treat vasomotor symptoms, although additional investigation is required to identify the lowest effective dose of the drug to minimize adverse effects.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.