Most Read Articles
Roshini Claire Anthony, 4 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
3 days ago
Serum 25-hydroxyvitamin D (25[OH]D) levels are significantly lower among patients with active uveitis than those with inactive uveitis and local population-based estimates, reports a study. In addition, vitamin D supplementation may help reduce uveitis activity, while sun exposure confers a beneficial effect to those with vitamin D deficiency.
2 days ago
The timing of direct oral anticoagulants (DOACs) administration, either within 3 days or ≥4 days of stroke onset, in patients with nonvalvular atrial fibrillation (AF) does not alter the risk of adverse outcomes such as stroke or systemic embolism, major bleeding, and death, as shown in a recent study.

Gabapentin improves symptoms of functional dyspepsia

14 Apr 2019

Treatment with gabapentin significantly improves symptoms of functional dyspepsia in a retrospective, open-label cohort of patients, reports an open-label study.

Sixty-two of the 110 patients with functional dyspepsia completed pre- and postgabapentin surveys. A 0.44-decrease (p<0.0001) was observed in the patients’ mean Patient Assessment of Gastrointestinal Disorders-Symptom Severity Index (PAGI-SYM), with significant changes in all subscales, including upper abdominal pain, lower abdominal pain and postprandial fullness, except for bloating.

An independent association was seen between worsening pretreatment symptom severity and improvement in multivariable analysis. Gabapentin treatment was discontinued in seven (11.3 percent) patients, with five (71.4 percent) stopping due to side effects.

There were significant improvements in overall, postprandial fullness and upper abdominal pain subscores in ≥50 percent of the cohort using the minimum significant PAGI-SYM score change threshold.

“Further studies are needed to place gabapentin in the functional dyspepsia treatment algorithm,” the authors said, adding that the findings were limited by the open-label design of the study.

Prior to evaluation, a baseline PAGI-SYM was completed by consecutive patients presenting to a tertiary motility clinic for the evaluation of functional dyspepsia without concurrent gastric emptying delay. Providers also initiated these patients on gabapentin for functional dyspepsia. Change in total PAGI-SYM score between initial and subsequent visits was the primary endpoint.

“Gabapentin has an established role in the treatment of neuropathic pain, with evidence supporting a benefit in visceral hypersensitivity. There is currently no data on the use of gabapentin for the treatment of functional dyspepsia,” the authors noted.

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
3 days ago
Serum 25-hydroxyvitamin D (25[OH]D) levels are significantly lower among patients with active uveitis than those with inactive uveitis and local population-based estimates, reports a study. In addition, vitamin D supplementation may help reduce uveitis activity, while sun exposure confers a beneficial effect to those with vitamin D deficiency.
2 days ago
The timing of direct oral anticoagulants (DOACs) administration, either within 3 days or ≥4 days of stroke onset, in patients with nonvalvular atrial fibrillation (AF) does not alter the risk of adverse outcomes such as stroke or systemic embolism, major bleeding, and death, as shown in a recent study.