Most Read Articles
Elvira Manzano, 2 days ago
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, 2 days ago
For individual with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
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Fungal infections may prove deadly for diabetics

10 Jan 2020
 Infectious fungal diseases (IFDs) are potentially lethal complications in patients with type 2 diabetes mellitus (T2DM) and are primarily caused by Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, a new study has found. Prolonged hyperglycaemia may further worsen outcomes.

This retrospective study included 120 T2DM patients (mean age, 60.5±11.7 years; 73 males) who had been diagnosed with IFDs after a median diabetes duration of 54 months. The overall diabetic inpatient population was 30,984, with an IFD prevalence rate of 0.4 percent. The corresponding rate in nondiabetics was 0.2 percent.

More than half of the IFDs were proven cases and a third were nosocomial cases. Yeast infections accounted for almost half of the infections, including 31 cases of candidiasis and 25 of cryptococcosis. The urinary tract was the most common site of involvement.

Majority of the participants received antifungal treatment (90.0 percent; n=108) or antifungal medications (83.3 percent; n=90). Twelve underwent operations alone, while six received medications after surgery. Over a median follow-up of -0.9 months, 28 patients died, yielding a mortality rate of 23.3 percent.

Levels of glycated haemoglobin were significantly higher in those who died (8.8±2.5 percent vs 7.7±2.1 percent; p=0.02) and may explain the worse prognosis. The same was true for diabetic nephropathy (50.0 percent vs 23.9 percent; p=0.01), having mixed fungal infections (28.6 percent vs 7.6 percent; p=0.01), coinfections (92.9 percent vs 34.8 percent; p<0.001) and disseminated IFD (25.0 percent vs 6.5 percent; p=0.01).

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Most Read Articles
Elvira Manzano, 2 days ago
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, 2 days ago
For individual with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
In patients with type 2 diabetes (T2D), postprandial hyperglycaemia and hypertriglyceridemia worsens survival outlook, finds a new study.