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4 days ago
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Fungal infections may prove deadly for diabetics

10 Jan 2020
 Infectious fungal diseases (IFDs) are potentially lethal complications in patients with type 2 diabetes mellitus (T2DM) and are primarily caused by Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, a new study has found. Prolonged hyperglycaemia may further worsen outcomes.

This retrospective study included 120 T2DM patients (mean age, 60.5±11.7 years; 73 males) who had been diagnosed with IFDs after a median diabetes duration of 54 months. The overall diabetic inpatient population was 30,984, with an IFD prevalence rate of 0.4 percent. The corresponding rate in nondiabetics was 0.2 percent.

More than half of the IFDs were proven cases and a third were nosocomial cases. Yeast infections accounted for almost half of the infections, including 31 cases of candidiasis and 25 of cryptococcosis. The urinary tract was the most common site of involvement.

Majority of the participants received antifungal treatment (90.0 percent; n=108) or antifungal medications (83.3 percent; n=90). Twelve underwent operations alone, while six received medications after surgery. Over a median follow-up of -0.9 months, 28 patients died, yielding a mortality rate of 23.3 percent.

Levels of glycated haemoglobin were significantly higher in those who died (8.8±2.5 percent vs 7.7±2.1 percent; p=0.02) and may explain the worse prognosis. The same was true for diabetic nephropathy (50.0 percent vs 23.9 percent; p=0.01), having mixed fungal infections (28.6 percent vs 7.6 percent; p=0.01), coinfections (92.9 percent vs 34.8 percent; p<0.001) and disseminated IFD (25.0 percent vs 6.5 percent; p=0.01).

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Most Read Articles
4 days ago
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
Tristan Manalac, 29 Mar 2020
While the 2019 coronavirus disease (COVID-19) is generally mild in children, infants appear to be particularly susceptible to severe and critical infections, a new study has found.
4 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
Pearl Toh, 2 days ago
It takes just less than 4 days for COVID-19 to spread from one person to another and cause symptoms, and more than 10 percent of the cases are infected by a person who has caught the virus but yet to show symptoms, recent studies suggest.