Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 5 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.

Fungal infections may prove deadly for diabetics

10 Jan 2020
 Infectious fungal diseases (IFDs) are potentially lethal complications in patients with type 2 diabetes mellitus (T2DM) and are primarily caused by Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, a new study has found. Prolonged hyperglycaemia may further worsen outcomes.

This retrospective study included 120 T2DM patients (mean age, 60.5±11.7 years; 73 males) who had been diagnosed with IFDs after a median diabetes duration of 54 months. The overall diabetic inpatient population was 30,984, with an IFD prevalence rate of 0.4 percent. The corresponding rate in nondiabetics was 0.2 percent.

More than half of the IFDs were proven cases and a third were nosocomial cases. Yeast infections accounted for almost half of the infections, including 31 cases of candidiasis and 25 of cryptococcosis. The urinary tract was the most common site of involvement.

Majority of the participants received antifungal treatment (90.0 percent; n=108) or antifungal medications (83.3 percent; n=90). Twelve underwent operations alone, while six received medications after surgery. Over a median follow-up of -0.9 months, 28 patients died, yielding a mortality rate of 23.3 percent.

Levels of glycated haemoglobin were significantly higher in those who died (8.8±2.5 percent vs 7.7±2.1 percent; p=0.02) and may explain the worse prognosis. The same was true for diabetic nephropathy (50.0 percent vs 23.9 percent; p=0.01), having mixed fungal infections (28.6 percent vs 7.6 percent; p=0.01), coinfections (92.9 percent vs 34.8 percent; p<0.001) and disseminated IFD (25.0 percent vs 6.5 percent; p=0.01).

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 5 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.