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Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Functional outcomes poorer in women than in men after ischaemic stroke

23 Sep 2017

While in-hospital mortality rate from ischaemic stroke is comparable between males and females, functional outcomes are poorer at discharge and at 6 months in females, a new study has shown.

In the study sample of 4,278 ischaemic stroke patients (mean age 69.9±12.12 years; 41.1 percent female), in-hospital mortality rates were found to be significantly elevated in females compared with males (p<0.01) based on univariate analysis.

However, after adjusting for age, risk factors and severity of stroke, the significant difference in mortality was attenuated (odds ratio [OR], 1.13; 95 percent CI, 0.66 to 1.93).

Univariate analysis also revealed that age >75 years elevated the risk of in-hospital mortality for females only, while stroke severity and increased intracranial pressure raised the risk for both sexes.

Multivariate analysis showed that cardioembolism stroke (OR, 0.35; 0.15 to 0.81; p=0.01) and atrial fibrillation (OR, 2.84; 1.38 to 5.85; p<0.01) significantly increased the risk of in-hospital mortality in females, but not in males.

Good outcomes 6 months after the stroke event were observed in 56.1 percent (n=1,813) of patients. Analysis by gender showed that only 47.4 percent (n=629) of females reported good outcomes as compared to 62.2 percent (n=1,184) of males. The difference reached statistical significance (p<0.01).

Old age (>75 years; p<0.01) significantly correlated with more severe strokes and hypertension (p=0.05) with poorer overall outcomes in females but not in males.

In contrast, diabetes mellitus significantly correlated with disease severity (p=0.04), neurological deterioration (p=0.05) and haemorrhagic transformation (p=0.03) in males only. Poor disease outcome was significantly associated with diabetes mellitus in both sexes (p<0.01 for both).

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.