Most Read Articles
26 Aug 2017
Elderly individuals with high levels of serum uric acid may be at an increased risk of dementia, particularly vascular or mixed dementia, a study suggests.
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Tocotrienols are one of the two classes of compounds generally known as vitamin E. Prominent researcher in pharmaceutical technology, Professor Yuen Kah Hay, recently spoke to MIMS Doctor about the neuroprotective benefits conferred by palm tocotrienols. He shared key insights from a clinical trial performed by his team and about the compound’s potential for clinical use.
Elvira Manzano, 01 Feb 2014

There is no benefit to using ibuprofen over paracetamol in most patients with upper respiratory tract infections (URTIs). Steam inhalation therapy also does not offer any advantage, research has shown.

Dr. Joseph Delano Fule Robles, 01 Mar 2017

The tau and Aβ amyloid pathways have emerged as possible novel targets in treating Alzheimer’s disease (AD), according to studies discussed at the recently concluded Hong Kong Pharmacy Conference.

Functional network changes may predict Alzheimer’s disease in elders

11 Aug 2017
Brain tricks: The fact that déjà vu occurs so randomly and rapidly—and in individuals without a medical condition—makes it difficult to study, and why and how the phenomenon occurs is up to much speculation.

Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.

The investigators categorized 45 CN elderly adults (mean age 75.2±4.7 years) into two groups according to the presence of Aβ: those with Aβ deposits (CN+; n=13) and those without (CN-; n=32). All participants were subjected to neuropsychological batteries, MEG, magnetic resonance imaging (MRI), 11C-Pittsburgh compound B-positron emission tomography (PiB-PET) and 18F-fluorodeoxyglucose PET (FDG-PET).

Functional connectivity (FC) analysis using the MEG results showed that network connectivity between the precuneus was significantly diminished in the CN+ (0.443±0.024) than in the CN- (0.470±0.022; p<0.001) group.

In contrast, FC between the precuneus and right inferior parietal lobule was significantly greater in the CN+ group (delta band, 0.366±0.008; theta band, 0.288±0.015) than in the CN- group (delta band, 0.343±0.011; theta band, 0.265±0.009; p<0.001 for both bands).

FC between the precuneus and right inferior parietal lobule was significantly greater for the delta and theta bands in the CN+ (0.365±0.011 and 0.287±0.009, respectively) than in the CN- group (0.343±0.010 and 0.265±0.010, respectively; p<0.001 for both).

All of the FC variables were either positively or negatively significantly correlated with PiB mean standardized uptake value ratio within default mode networks indicating significant linear associations with cerebral amyloid depositions.

Notably, quantitative analyses of FDG-PET and MRI volumetric data showed that there was no significant difference between the CN+ and CN- groups. FDG-PET scores were not significantly correlated with FC values.

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Most Read Articles
26 Aug 2017
Elderly individuals with high levels of serum uric acid may be at an increased risk of dementia, particularly vascular or mixed dementia, a study suggests.
14 Jan 2016
Tocotrienols are one of the two classes of compounds generally known as vitamin E. Prominent researcher in pharmaceutical technology, Professor Yuen Kah Hay, recently spoke to MIMS Doctor about the neuroprotective benefits conferred by palm tocotrienols. He shared key insights from a clinical trial performed by his team and about the compound’s potential for clinical use.
Elvira Manzano, 01 Feb 2014

There is no benefit to using ibuprofen over paracetamol in most patients with upper respiratory tract infections (URTIs). Steam inhalation therapy also does not offer any advantage, research has shown.

Dr. Joseph Delano Fule Robles, 01 Mar 2017

The tau and Aβ amyloid pathways have emerged as possible novel targets in treating Alzheimer’s disease (AD), according to studies discussed at the recently concluded Hong Kong Pharmacy Conference.