Most Read Articles
19 Mar 2018
Hydrocephalus following traumatic brain injury (TBI) is relatively uncommon in children than it is in adults, a recent study has shown. Risk factors include age, comorbidities, subarachnoid haemorrhage (SAH) and subdural haematoma (SDH).
17 Mar 2018
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.
24 Mar 2018
Early initiation of plasma exchange (PLEX) during severe attacks of neuromyelitis optica spectrum disorder (NMO-SD) delivers improved clinical benefit, according to a new study, adding that giving PLEX to patients as a rescue therapy only after steroid failure may be harmful.
27 Mar 2018
The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention is effective for elderly adults at risk of dementia regardless of baseline cognition, sociodemographic and cardiovascular characteristics, a recent study has shown.

Functional network changes may predict Alzheimer’s disease in elders

11 Aug 2017
Brain tricks: The fact that déjà vu occurs so randomly and rapidly—and in individuals without a medical condition—makes it difficult to study, and why and how the phenomenon occurs is up to much speculation.

Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.

The investigators categorized 45 CN elderly adults (mean age 75.2±4.7 years) into two groups according to the presence of Aβ: those with Aβ deposits (CN+; n=13) and those without (CN-; n=32). All participants were subjected to neuropsychological batteries, MEG, magnetic resonance imaging (MRI), 11C-Pittsburgh compound B-positron emission tomography (PiB-PET) and 18F-fluorodeoxyglucose PET (FDG-PET).

Functional connectivity (FC) analysis using the MEG results showed that network connectivity between the precuneus was significantly diminished in the CN+ (0.443±0.024) than in the CN- (0.470±0.022; p<0.001) group.

In contrast, FC between the precuneus and right inferior parietal lobule was significantly greater in the CN+ group (delta band, 0.366±0.008; theta band, 0.288±0.015) than in the CN- group (delta band, 0.343±0.011; theta band, 0.265±0.009; p<0.001 for both bands).

FC between the precuneus and right inferior parietal lobule was significantly greater for the delta and theta bands in the CN+ (0.365±0.011 and 0.287±0.009, respectively) than in the CN- group (0.343±0.010 and 0.265±0.010, respectively; p<0.001 for both).

All of the FC variables were either positively or negatively significantly correlated with PiB mean standardized uptake value ratio within default mode networks indicating significant linear associations with cerebral amyloid depositions.

Notably, quantitative analyses of FDG-PET and MRI volumetric data showed that there was no significant difference between the CN+ and CN- groups. FDG-PET scores were not significantly correlated with FC values.

Editor's Recommendations
Most Read Articles
19 Mar 2018
Hydrocephalus following traumatic brain injury (TBI) is relatively uncommon in children than it is in adults, a recent study has shown. Risk factors include age, comorbidities, subarachnoid haemorrhage (SAH) and subdural haematoma (SDH).
17 Mar 2018
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.
24 Mar 2018
Early initiation of plasma exchange (PLEX) during severe attacks of neuromyelitis optica spectrum disorder (NMO-SD) delivers improved clinical benefit, according to a new study, adding that giving PLEX to patients as a rescue therapy only after steroid failure may be harmful.
27 Mar 2018
The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention is effective for elderly adults at risk of dementia regardless of baseline cognition, sociodemographic and cardiovascular characteristics, a recent study has shown.