Most Read Articles
23 Apr 2018
Long‐term treatment with perampanel in the adjunctive setting appears to provide improved seizure control without raising new safety/tolerability signals in patients with epilepsy, particularly those with secondarily generalized seizures at baseline, according to the results of an open-label extension of phase III trials.
Audrey Abella, 20 Mar 2020
The addition of highly purified cannabidiol (CBD) into an antiepileptic regimen led to reductions in convulsive seizure rates in children with Dravet syndrome (DS), the GWPCARE2* study has shown.
27 May 2020
High rather than low levels of neonatal 25(OH)D3 pose an increased risk of incident epilepsy in early childhood, a finding that may be attributed to chance, confounding, or late gestational vitamin D exposure, according to a study.
Jairia Dela Cruz, 29 Jan 2020
In the treatment of idiopathic generalized epilepsy, switching from valproate to other antiepileptic drugs due to potential childbearing issues may prove detrimental, heightening the risk of poor seizure control, as shown in a recent study.

Functional brain connectivity predicts antidepressant response in major depression

04 Oct 2019

Specific functional network-based moderators of treatment outcome have been identified, and these involve brain networks affected by major depression, reports a study. In addition, a favourable response for an antidepressant medication appears to be influenced by functional connectivity patterns of brain regions between and within networks.

“Major depressive disorder is associated with aberrant resting-state functional connectivity across multiple brain networks supporting emotion processing, executive function and reward processing,” the authors said.

A total of 279 participants in the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study underwent structural and resting-state functional magnetic resonance imaging at baseline and were then randomized to receive either sertraline or placebo treatment for 8 weeks.

The authors computed the functional connectivity between brain regions using a region of interest-based approach. They then identified brain regions that moderated (ie, differentially predicted) outcomes between the sertraline and placebo arms using linear mixed-model intent-to-treat analyses.

Several within- and between-network connectivity patterns were involved in the prediction of response to sertraline. Of note, higher connectivity within the default mode network was a predictor of better outcomes for sertraline. Greater between-network connectivity of the default mode and executive control networks also predicted favourable outcomes for the antidepressant drug.

On the other hand, between-network hippocampal connectivity predicted (in opposite directions) the outcomes for both placebo and sertraline, according to the authors.

Sertraline is a selective serotonin reuptake inhibitor that affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety or obsessive-compulsive symptoms. [https://www.drugs.com/sertraline.html]

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Most Read Articles
23 Apr 2018
Long‐term treatment with perampanel in the adjunctive setting appears to provide improved seizure control without raising new safety/tolerability signals in patients with epilepsy, particularly those with secondarily generalized seizures at baseline, according to the results of an open-label extension of phase III trials.
Audrey Abella, 20 Mar 2020
The addition of highly purified cannabidiol (CBD) into an antiepileptic regimen led to reductions in convulsive seizure rates in children with Dravet syndrome (DS), the GWPCARE2* study has shown.
27 May 2020
High rather than low levels of neonatal 25(OH)D3 pose an increased risk of incident epilepsy in early childhood, a finding that may be attributed to chance, confounding, or late gestational vitamin D exposure, according to a study.
Jairia Dela Cruz, 29 Jan 2020
In the treatment of idiopathic generalized epilepsy, switching from valproate to other antiepileptic drugs due to potential childbearing issues may prove detrimental, heightening the risk of poor seizure control, as shown in a recent study.