Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.
Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.

Fructose substitution offers little impact on fasting blood glucose, insulin, triglycerides

17 Aug 2017

Individuals with impaired glucose tolerance or type 2 diabetes (T2D) may benefit from the substitution of fructose for glucose or sucrose in food or beverages, suggests a systematic review and meta-analysis.

Researchers searched Medline, Embase, the Cochrane Library, the WHO International Clinical Trials Registry Platform Search Portal and clinicaltrials.gov until 26 April 2016 to review the evidence for a reduction in fasting glycaemic and insulinaemic markers after chronic, isoenergetic replacement of glucose or sucrose in foods or beverages by fructose.

Included were randomized controlled trials of isoenergetic replacement of glucose, sucrose or both by fructose in adults or children with or without diabetes. The trials lasted ≥2 weeks and measured fasting blood glucose (FBG). Main outcome measures included FBG and insulin, fasting triglycerides, blood lipoproteins and glycated haemoglobin (HbA1c) and body weight.

There were 14 comparison arms from 11 trials, involving 277 patients, included in the meta-analysis. The length of the studies varied from 2 to 10 weeks (mean 28 days), while doses of fructose were between 40 and 150 g/day (mean 68 g/day).

In some subgroups, substituting fructose led to significantly but only slightly lowered FBG (−0.14 mmol/L; 95 percent CI, −0.24 to −0.036 mmol/L), HbA1c (‒10 g/L; ‒12.90 to ‒7.10 g/L impaired glucose tolerance; ‒6 g/L; ‒8.47; ‒3.53 g/L normoglycaemia), triglycerides (‒0.08 mmol/L; ‒0.14 to ‒0.02 mmol/L) and body weight (‒1.40 kg; ‒2.07 to ‒0.74 kg).

No effect was seen on fasting blood insulin or blood lipids, according to researchers, adding that high-quality studies in individuals with impaired glucose tolerance or T2D are warranted.

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Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.
Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.