Most Read Articles
13 Sep 2020
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 4 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
6 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


Frailty worsens surgery outcomes in old patients

27 Feb 2020

Frailty is associated with poor 1-year outcomes in elderly patients undergoing emergency general surgery (EGS), a recent study reports.

Researchers conducted a retrospective analysis of 468,459 elderly adults who underwent partial colectomy, small bowel resection, peptic ulcer disease repair, adhesiolysis or laparotomy. A validated claims-based frailty index was used to identify those who were prefrail, mildly frail and moderately-to-severely frail.

A total of 175,336 participants (37.4 percent) were prefrail, while 12.4 percent (n=58,056) and 3.6 percent (n=16,803) were mildly and moderately-to-severely frail, respectively; the remaining 218,264 were nonfrail. Fourteen percent of patients with any frailty received palliative care during index hospitalization.

The 30-day mortality was 15.7 percent (n=73,666), which grew to 24.7 percent (n=115,687) by day 180 and further to 30.4 percent (n=102,365) at 1 year. Crude mortality was highest among those with the most severe frailty.

Multivariable analysis confirmed that the risk of 30-day mortality was significantly elevated in those with prefrailty, mild and moderate-to-severe frailty, relative to the nonfrail comparators. These effects were consistent at 180 days and at 1 year. Notably, those at the highest levels of frailty were more than twice as likely to die at 1 year than nonfrail participants (hazard ratio, 2.30, 95 percent confidence intervals, 2.24–2.35).

Similarly, 1-year postdischarge outcomes, such as emergency department visits, rehospitalizations, stay in the intensive care and total hospital encounters, were all significantly worse in patients with any frailty. Greater severities of frailty resulted in higher risks across all outcomes.

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Most Read Articles
13 Sep 2020
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 4 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
6 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.