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Frailty significantly predicts overactive bladder

03 Jun 2017

Older patients with overactive bladder (OAB) appear to have increased frailty compared with individuals seeking care for other nononcologic urologic diagnosis, with frailty being a significant predictor of OAB, a study has found.

The prospective study included 201 OAB patients and 1,162 non-OAB individuals aged ≥65 years. All patients underwent a timed up-and-go test (TUGT), a measure of frailty, and were thereby categorized according to the results: fast (≤10 seconds), intermediate (11 to 14 seconds) and slow (≥15 seconds).

Logistic regression analysis was performed to examine the relationship between frailty and OAB. Adjustments for age, gender and race were made.

Results revealed that patients with OAB were significantly slower in the execution of TUGT compared with controls (13.7 vs 10.9 seconds; p<0.0001), with the proportion of individuals categorized as slow or frail being higher in the OAB group (32.3 vs 11.0 percent).

On multivariable analysis, slower TUGT was a significant predictor of OAB (adjusted odds ratio [OR], 3.0; 95 percent CI, 2.0 to 4.8). Age showed no independent association with the urologic condition (p>0.05).

The findings suggest that OAB patients aged ≥65 years are significantly frailer than individuals without the condition, and that frailty significantly predicts OAB. In light of the data, “frailty should be considered when caring for older patients with OAB, and OAB should be assessed when caring for frail older patients,” researchers said.

OAB is characterized by urinary frequency, nocturia and urgency with or without incontinence. In older adults, urinary incontinence and lower urinary tract symptoms are highly prevalent and are strongly associated with frailty. [LUTS 2012;4:48–55]

Frailty as a concept has been defined as “the accumulation of impairments” and as a phenotypic model. As a phenotype, frailty is said to be a biologic syndrome of decreased reserve and resistance to stressors, as a result of cumulative declines across multiple physiologic systems and causing vulnerability to adverse outcomes. By either definition, greater frailty is strongly linked to elevated mortality and risk of institutionalization. [Clin Pract 2014;11:431–440]

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng, 10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
11 Sep 2019
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
Pearl Toh, 18 hours ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.