Most Read Articles
Pearl Toh, Yesterday
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Frailty predicts morbidity, mortality in elderly patients needing emergency colorectal surgery

19 Sep 2020

Frailty is a predictor of morbidity, mortality, and loss of independence in elderly patients needing emergency colorectal surgery, suggests a recent study.

The investigators identified elderly patients aged 65 years who underwent emergency colorectal resection between 2012 and 2016 from the American College of Surgeons National Surgical Quality Improvement Program population database. They also calculated the five-item modified frailty index (mFI-5) and stratified patients into groups 0, 1, or 2+.

Outcome measures were the prevalence of frailty and its impact on 30-day postoperative morbidity, mortality, reoperation, length of hospital stay (LOS), discharge destination, and readmission.

Of the 10,025 patients (median age, 75 years) included in the study, 41.8 percent were men. Majority of the patients (87.7 percent) had an American Society of Anaesthesiologists fitness grade of III or greater, and 3,129 (31.2 percent) were frail (mFI-5 group 2+).

One-third of patients had major morbidity, while 15.9 percent succumbed to postoperative death. Fifty-two percent of patients had a prolonged hospital stay and 11 percent were readmitted. Majority of the patients (88.0 percent) lived independently prior to surgery, but only 45.4 percent were discharged home directly.

Frailty (mFI‐5 2+) was associated with mortality, overall and major morbidity, reoperation, prolonged LOS, discharge to an institution, and readmission, but frailty was independent of sex.

“Frailty is associated with advancing age and may result in adverse postoperative outcomes,” the investigators said. “A suspected growing elderly population needing emergency colorectal surgery stimulated this study of the prevalence and impact of frailty.”

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Most Read Articles
Pearl Toh, Yesterday
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.