Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Frailty predicts morbidity, mortality in elderly patients needing emergency colorectal surgery

19 Sep 2020

Frailty is a predictor of morbidity, mortality, and loss of independence in elderly patients needing emergency colorectal surgery, suggests a recent study.

The investigators identified elderly patients aged 65 years who underwent emergency colorectal resection between 2012 and 2016 from the American College of Surgeons National Surgical Quality Improvement Program population database. They also calculated the five-item modified frailty index (mFI-5) and stratified patients into groups 0, 1, or 2+.

Outcome measures were the prevalence of frailty and its impact on 30-day postoperative morbidity, mortality, reoperation, length of hospital stay (LOS), discharge destination, and readmission.

Of the 10,025 patients (median age, 75 years) included in the study, 41.8 percent were men. Majority of the patients (87.7 percent) had an American Society of Anaesthesiologists fitness grade of III or greater, and 3,129 (31.2 percent) were frail (mFI-5 group 2+).

One-third of patients had major morbidity, while 15.9 percent succumbed to postoperative death. Fifty-two percent of patients had a prolonged hospital stay and 11 percent were readmitted. Majority of the patients (88.0 percent) lived independently prior to surgery, but only 45.4 percent were discharged home directly.

Frailty (mFI‐5 2+) was associated with mortality, overall and major morbidity, reoperation, prolonged LOS, discharge to an institution, and readmission, but frailty was independent of sex.

“Frailty is associated with advancing age and may result in adverse postoperative outcomes,” the investigators said. “A suspected growing elderly population needing emergency colorectal surgery stimulated this study of the prevalence and impact of frailty.”

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.