Most Read Articles
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
6 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.

Frailty Index, Comprehensive Geriatric Assessment predict mortality in seniors after colorectal surgery

22 Sep 2019

The 40-item Frailty Index (FI) and the Comprehensive Geriatric Assessment (CGA) are similarly predictive of 1-year mortality in elderly adults undergoing colorectal surgery, a recent study has found.

Researchers enrolled 99 elderly adults (mean age, 80.18±5.88 years; 62 percent male) who were scheduled to undergo elective gastrointestinal surgery. Geriatric assessment was performed 0–14 days before the procedure using the CGA and the 40-item FI. A Barthel Index telephone interview was administered after a year to assess long-term outcomes.

Colorectal cancer was the most prevalence diagnosis (88 percent), followed by gastric cancer (12 percent). More than half (63.6 percent) of the participants had deficits in more than three CGA domains and thus had a frail phenotype. The FI, in comparison, identified 50.5 percent as prefrail and 40.5 percent as frail.

Nineteen deaths were reported a year after surgery, resulting in a 1-year mortality rate of 19 percent. Receiver operating characteristic curve analysis revealed comparable capabilities of CGA (area under the curve [AUC], 0.72, 95 percent CI, 0.58–0.86) and FI (AUC, 0.70, 0.54–0.89; p=0.61) to predict mortality.

However, at a cutoff value of 0.19, FI showed a slight edge, with a sensitivity of 87.5 percent and specificity of 51.1 percent. CGA achieved its best predictive value at a threshold value of 3, where the sensitivity and specificity were 87.5 percent and 44.3 percent, respectively.

Multivariate logistic regression analysis identified decline in functional status (odds ratio [OR], 1.45, 95 percent CI, 1.03–2; p=0.033) and cancer stage (OR, 3.28, 0.91–11.8; p=0.069) as significant predictors of 1-year mortality.

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Most Read Articles
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
6 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.