Most Read Articles
Tristan Manalac, 11 Jul 2018
Gestational exposure to grain products fortified with folic acid appears to be linked to a lower risk of psychosis in offspring, according to a recent study.
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
4 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.

Fosmidomycin-piperaquine combo viable alternative to artemisinin for malaria

24 Jan 2018
Only certain species of mosquitoes of the Anopheles genus – and only females of those species – can transmit malaria.

The fosmidomycin-piperaquine combination therapy appears to have high clinical efficacy and acceptable safety for the treatment of uncomplicated Plasmodium falciparum malaria, and may thus be considered a viable artemisinin substitute, a recent study shows.

The study included both adult and paediatric malaria patients with initial parasite counts between 1,000 and 150,000 per µL. All participants received 30 mg/kg of oral fosmidomycin twice daily and 16 mg/kg of oral piperaquine once daily for 3 days.

After 28 days of follow-up, all 83 participants had adequate clinical and parasitological response (ACPR).  Two recorded treatment failures were identified as reinfections. Twelve late parasitological failures were reported but were identified as new infections. The resulting polymerase chain reaction-corrected ACPR rate at day 63 was 100 percent.

At day 7, all participants tested negative for malaria. The overall proportion of patients with gametocytes at days 0 and 7 were 5 and 3 percent, respectively. Rapid treatment response was reported in all participants.

Three adults and 49 children, who were anaemic at baseline, were observed to have increased haemoglobin levels 7 days after treatment. Five cases with baseline platelet counts of <100,000 mm3 showed normal levels by day 7. On the other hand, two patients experienced a reduction in haemoglobin level on day 3 but did not show any clinical consequences.

There was a total of 97 adverse events recorded, experienced by 55 patients. The majority of events were of the gastrointestinal tract and the upper and lower respiratory tract (24 percent for both). These were followed by skin lesions (13 percent), headaches and fevers (12 percent), anaemia (5 percent), and urogenital schistosomiasis infections (4 percent).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Tristan Manalac, 11 Jul 2018
Gestational exposure to grain products fortified with folic acid appears to be linked to a lower risk of psychosis in offspring, according to a recent study.
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
4 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.