Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
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Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
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Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Foot massage therapy eases restless leg syndrome

Tristan Manalac
09 Apr 2020

The novel MMF07 foot massager appears to be an effective treatment option for restless leg syndrome (RLS), according to a recent study.

“Safe and effective nonpharmacologic treatments are needed for RLS,” researchers said. “RLS severity scores, the primary study outcome measure, improved the greatest in those using the massager compared to those in the other groups.”

The pilot randomized controlled trial included 28 RLS patients who received no active intervention (n=7), the foot massage therapy alone (n=8), heat therapy alone (n=6), or both the foot massage device and heat therapy (n=7). Twenty-six patients were receiving oral medication for RLS symptoms. All four intervention arms were balanced in terms of RLS severity. [PLoS One 2020;15:e0230951]

After 4 weeks of trial, patients who received the massage therapy alone had a mean RLS severity score of 12.3±4.2. The no-intervention controls, on the other hand, had a score of 21.3±8.5. The resulting average difference of –9.0 points was statistically significant (95 percent confidence interval [CI], –16.3 to –1.7; p=0.017).

Notably, no significant benefit was reported for heat therapy alone (average difference, –3.6, 95 percent CI, –11.8 to 3.9) or for the combination intervention (average difference, –4.4, 95 percent CI, –12.0 to 3.1).

“The fact that simultaneous administration of heat and massage treatment was not additive, but rather less than massage alone suggests that these interactions need to be considered,” the researchers said, adding that while thermotherapy has seen utility in easing pain, empirical evidence surrounding its efficacy remains anecdotal.

The researchers also detected significant benefits of massage device on the secondary outcome of sleep quality, as measured by the Medical Outcome Sleep Scale. Both the massage alone (p=0.005) and heat therapy alone (p=0.026) groups saw significant improvements relative to controls, but not those who received the combination (p=0.11). Quality of life, on the other hand, was significantly better in all treatment arms.

Important limitations need to be taken stock of, including the small sample size, relatively short follow-up period and the lack of objective biomarkers for RLS.

“Given the open design of this study where participants were aware of their treatment modality, we recognize that the observed improvements reported by patients may be in part due to those patients’ belief in the benefit of the treatments, rather than the treatments themselves,” the researchers said. “We did have a control arm, however future work may evaluate this potential placebo effect with a placebo-controlled group.

“Larger trials of longer duration are warranted to further investigate the clinical meaningfulness of vibratory stimuli and heat in the treatment of RLS as these nonpharmacologic interventions may be effective, safe and economical treatment options,” they added.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
3 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.