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Food-based diet intervention effective against Crohn’s disease

10 Apr 2019
Crohn’s is not the end of the world, as Kathleen Baker’s silver medal proves

An individualized, food-based diet may be a potential treatment approach for patients with active Crohn’s disease (CD), successfully replicating microbiome changes elicited by exclusive enteral nutrition (EEN) and reducing gut inflammation, a recent study has shown.

Researchers tested the efficacy of the CD treatment-with-eating diet (CD-TREAT) approach on five children with active luminal disease. All participants had previously been treated with EEN, three were receiving thiopurine monotherapy, one was on a combination regimen of thiopurine and antitumour necrosis factor, and the final participant had no background treatments.

Eighty percent (n=4) completed all 8 weeks of treatment, while the one remaining child discontinued after 9 days due to symptom exacerbation.

After 4 weeks of CD-TREAT intervention, 60 percent (n=3) of the children showed clinical response, earning score changes in the Paediatric Crohn’s Disease Activity Index (PCDAI) worth >17.5 points. Forty percent (n=2) were in clinical remission (PCDAI score <12.5).

After the 8-week programme, all children still enrolled (80 percent; n=4) were positive for clinical response while 60 percent (n=3) were in clinical remission. By the end of the study period, the mean PCDAI score of the group dropped from 32.5±7.5 at baseline to 7.5±7.4 (p=0.005).

Similarly, mean concentrations of faecal calprotectin dropped significantly from 1,960±1,104 mg/kg at baseline to 981±690 mg/kg at 4 weeks and 1,042±776 mg/kg at 8 weeks.

Future efforts are required to confirm the findings through large and well-controlled clinical trials and mechanistic studies, said researchers. If verified, CD-TREAT may be an effective approach to CD patients for whom EEN is unacceptable.

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Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 4 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
4 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.