Most Read Articles
Tristan Manalac, 5 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 13 May 2019
The selective cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) effectively improves influenza symptoms in adolescent patients and those at high risk for influenza complications, according to two subanalyses of the CAPSTONE studies presented at ECCMID 2019.

Food-based diet intervention effective against Crohn’s disease

10 Apr 2019
Crohn’s is not the end of the world, as Kathleen Baker’s silver medal proves

An individualized, food-based diet may be a potential treatment approach for patients with active Crohn’s disease (CD), successfully replicating microbiome changes elicited by exclusive enteral nutrition (EEN) and reducing gut inflammation, a recent study has shown.

Researchers tested the efficacy of the CD treatment-with-eating diet (CD-TREAT) approach on five children with active luminal disease. All participants had previously been treated with EEN, three were receiving thiopurine monotherapy, one was on a combination regimen of thiopurine and antitumour necrosis factor, and the final participant had no background treatments.

Eighty percent (n=4) completed all 8 weeks of treatment, while the one remaining child discontinued after 9 days due to symptom exacerbation.

After 4 weeks of CD-TREAT intervention, 60 percent (n=3) of the children showed clinical response, earning score changes in the Paediatric Crohn’s Disease Activity Index (PCDAI) worth >17.5 points. Forty percent (n=2) were in clinical remission (PCDAI score <12.5).

After the 8-week programme, all children still enrolled (80 percent; n=4) were positive for clinical response while 60 percent (n=3) were in clinical remission. By the end of the study period, the mean PCDAI score of the group dropped from 32.5±7.5 at baseline to 7.5±7.4 (p=0.005).

Similarly, mean concentrations of faecal calprotectin dropped significantly from 1,960±1,104 mg/kg at baseline to 981±690 mg/kg at 4 weeks and 1,042±776 mg/kg at 8 weeks.

Future efforts are required to confirm the findings through large and well-controlled clinical trials and mechanistic studies, said researchers. If verified, CD-TREAT may be an effective approach to CD patients for whom EEN is unacceptable.

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Most Read Articles
Tristan Manalac, 5 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 13 May 2019
The selective cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) effectively improves influenza symptoms in adolescent patients and those at high risk for influenza complications, according to two subanalyses of the CAPSTONE studies presented at ECCMID 2019.