Food-based diet intervention effective against Crohn’s disease
An individualized, food-based diet may be a potential treatment approach for patients with active Crohn’s disease (CD), successfully replicating microbiome changes elicited by exclusive enteral nutrition (EEN) and reducing gut inflammation, a recent study has shown.
Researchers tested the efficacy of the CD treatment-with-eating diet (CD-TREAT) approach on five children with active luminal disease. All participants had previously been treated with EEN, three were receiving thiopurine monotherapy, one was on a combination regimen of thiopurine and antitumour necrosis factor, and the final participant had no background treatments.
Eighty percent (n=4) completed all 8 weeks of treatment, while the one remaining child discontinued after 9 days due to symptom exacerbation.
After 4 weeks of CD-TREAT intervention, 60 percent (n=3) of the children showed clinical response, earning score changes in the Paediatric Crohn’s Disease Activity Index (PCDAI) worth >17.5 points. Forty percent (n=2) were in clinical remission (PCDAI score <12.5).
After the 8-week programme, all children still enrolled (80 percent; n=4) were positive for clinical response while 60 percent (n=3) were in clinical remission. By the end of the study period, the mean PCDAI score of the group dropped from 32.5±7.5 at baseline to 7.5±7.4 (p=0.005).
Similarly, mean concentrations of faecal calprotectin dropped significantly from 1,960±1,104 mg/kg at baseline to 981±690 mg/kg at 4 weeks and 1,042±776 mg/kg at 8 weeks.
Future efforts are required to confirm the findings through large and well-controlled clinical trials and mechanistic studies, said researchers. If verified, CD-TREAT may be an effective approach to CD patients for whom EEN is unacceptable.