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Folate defends against adverse reproductive effects of traffic-related pollution

03 Aug 2019

Supplemental folate intake appears to mitigate the adverse effect of exposure to raised levels of nitrogen dioxide (NO2) on the likelihood of a live birth in women undergoing assisted reproductive technologies (ART), according to a study.

Researchers examined 304 women (513 cycles; mean age, 35.2 years; mean body mass index, 24.3 kg/m2) presenting to a fertility centre. Women in this cohort had high intake levels of total (median, 1,100 µg/day) and supplemental folate (median, 571 µg/day). Overall, 16 percent and 20 percent of the population consumed <400 and 1,000 µg/day of supplemental folate, respectively.

In 468 of the initiated cycles with at least one embryo transferred, 290 resulted in implantation, 257 in clinical pregnancy and 206 in live birth. Women contributed an average of 1.7 ART cycles.

During the study period, the median (10th–90th percentile) estimated air pollution concentrations in the 3 months prior to ART were 22.9 ppb for NO2, 34.2 ppb for ozone (O3), 8.5 µg/m3 for fine particulate matter (PM2.5) and 0.49 µg/m3 for black carbon. Correlations between pollutants were modest, with the highest magnitude observed for NO2 and black carbon (r, 0.39). Ozone showed weak inverse correlations with NO2 (r, –0.13) and black carbon (r, –0.22).

Supplemental folate intake significantly modified the association between NO2 exposure and live birth (p=0.01). Among women with supplemental folate intake level of <800 μg/day, the likelihood of live birth decreased by 24 percent for every 20-ppb increase in NO2 exposure. This association was not observed among women with supplemental folate intake levels of ≥800 μg/day.

Furthermore, folate did not modify the associations between other air pollutants and live birth.

The findings indicate that high supplemental folate intake may protect against the adverse reproductive consequences of traffic-related air pollution, the researchers said.

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Most Read Articles
Yesterday
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
6 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 12 Nov 2019
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
Jairia Dela Cruz, 4 days ago
Many patients with nonvalvular atrial fibrillation (NVAF) in Thailand use anticoagulants, but the uptake of nonvitamin-K oral anticoagulants remains suboptimal despite showing an upward trend, according to data from the COOL-AF registry presented at the European Society of Cardioloy (ESC) Asia Congress 2019 with APSC and AFC.