Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.

Folate, vitamin B12 implicated in gestational diabetes

18 Dec 2020

Women with elevated red blood cell (RBC) folate and vitamin B12 concentrations in early pregnancy are at risk of developing gestational diabetes mellitus (GDM), a study has found.

The analysis used data from 1,058 pregnant women (mean age, 30.24 years; mean body mass index, 21.03 kg/m2) included within the Shanghai Preconception Cohort Study. RBC folate and vitamin B12 measurements were conducted at recruitment (between 9 and 13 gestational weeks), and all women contributed three blood samples for glucose measurements under oral glucose tolerance test.

Of the women, 38.75 percent had a family history of diabetes, 15.60 percent reported smoking exposure, and 13.42 percent consumed alcohol during gestation. Most of the women (63.7 percent) received folic acid supplements, with most of them taking compound vitamin supplements. The median concentrations of RBC folate, serum folate, and vitamin B12 were 385.92 ng/mL, 14.39 ng/mL, and 405.93 pg/mL, respectively.

Between 24 and 28 weeks of gestation, 180 cases (17.01 percent) of GDM occurred. RBC folate and vitamin B12 levels were significantly higher in women with versus without GDM (p=0.045 and p=0.002, respectively) and positively correlated with 1-h and 2-h serum glucose.

Multivariable logistic regression analyses revealed that daily folic acid supplementation in early pregnancy contributed to increased GDM risk (odds ratio [OR], 1.73, 95 percent confidence interval [CI], 1.19–2.53; p=0.004). RBC folate ≥600 versus <400 ng/mL levels were associated with about 1.6-fold higher odds of GDM (OR, 1.58, 95 percent CI, 1.032.41; p=0.033).

Likewise, vitamin B12 showed a positive association with GDM risk (per 100 pg/mL: OR, 1.14; p=0.002).

There was no significant association seen between GDM and serum folate and percentile ratio of RBC folate/vitamin B12.

More studies are needed to determine the appropriate levels of folate and vitamin B12 in early pregnancy that are essential for maternal and offspring health.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.