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Pearl Toh, 2 days ago
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Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Flurpiridaz PET holds promise as new tracer for CAD detection

01 Aug 2020

Fluorine-18 flurpiridaz positron emission tomography (PET) myocardial perfusion imaging appears to be noninferior to technetium-99m–labeled single photon emission computed tomography (SPECT) for the detection of coronary artery disease (CAD), as well as the assessment of women, obese individuals, and patients undergoing pharmacological stress testing, results of a phase III trial have shown.

A total of 795 patients with known or suspected CAD from 72 clinical sites in the US, Canada, and Finland participated in this phase III prospective multicentre clinical study. Of the 755 participants who were evaluable (mean age, 62.3 years; 31 percent women) 55 percent had body mass index ≥30 kg/m2 and 71 percent had pharmacological stress.

Patients then underwent 1-day rest-stress (pharmacological or exercise) flurpiridaz PET and 1- or 2-day rest-stress Tc-99m–labeled SPECT and invasive coronary angiography (ICA). Three experts, who were blinded to clinical and ICA data, read the images.

Sensitivity of flurpiridaz PET (for detection of ≥50 percent stenosis by ICA) was 71.9 percent (95 percent confidence interval [CI], 67.0–76.3) and was significantly higher (p<0.001) than that with SPECT (53.7 percent, 95 percent CI, 48.5–58.8), but its specificity failed to meet the prespecified noninferiority criterion (76.2 percent, 95 percent CI, 71.8–80.1 vs 86.6 percent, 95 percent CI, 83.2–89.8; p=NS).

In receiver-operating characteristic curve analysis, flurpiridaz PET showed superior discrimination of CAD in the overall population, in women, obese individuals, and patients undergoing pharmacological stress testing (p<0.001 for all) compared with SPECT.

Flurpiridaz PET was also superior to SPECT for the following: defect size (p<0.001), image quality (p<0.001), diagnostic certainty (p<0.001), and radiation exposure (6.1±0.4 vs 13.4±3.2 mSv; p<0.001). In addition, flurpiridaz was safe and well tolerated.

A second phase III trial by the Food and Drug Administration is ongoing. 

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Most Read Articles
Pearl Toh, 2 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.