Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Flurpiridaz PET holds promise as new tracer for CAD detection

01 Aug 2020

Fluorine-18 flurpiridaz positron emission tomography (PET) myocardial perfusion imaging appears to be noninferior to technetium-99m–labeled single photon emission computed tomography (SPECT) for the detection of coronary artery disease (CAD), as well as the assessment of women, obese individuals, and patients undergoing pharmacological stress testing, results of a phase III trial have shown.

A total of 795 patients with known or suspected CAD from 72 clinical sites in the US, Canada, and Finland participated in this phase III prospective multicentre clinical study. Of the 755 participants who were evaluable (mean age, 62.3 years; 31 percent women) 55 percent had body mass index ≥30 kg/m2 and 71 percent had pharmacological stress.

Patients then underwent 1-day rest-stress (pharmacological or exercise) flurpiridaz PET and 1- or 2-day rest-stress Tc-99m–labeled SPECT and invasive coronary angiography (ICA). Three experts, who were blinded to clinical and ICA data, read the images.

Sensitivity of flurpiridaz PET (for detection of ≥50 percent stenosis by ICA) was 71.9 percent (95 percent confidence interval [CI], 67.0–76.3) and was significantly higher (p<0.001) than that with SPECT (53.7 percent, 95 percent CI, 48.5–58.8), but its specificity failed to meet the prespecified noninferiority criterion (76.2 percent, 95 percent CI, 71.8–80.1 vs 86.6 percent, 95 percent CI, 83.2–89.8; p=NS).

In receiver-operating characteristic curve analysis, flurpiridaz PET showed superior discrimination of CAD in the overall population, in women, obese individuals, and patients undergoing pharmacological stress testing (p<0.001 for all) compared with SPECT.

Flurpiridaz PET was also superior to SPECT for the following: defect size (p<0.001), image quality (p<0.001), diagnostic certainty (p<0.001), and radiation exposure (6.1±0.4 vs 13.4±3.2 mSv; p<0.001). In addition, flurpiridaz was safe and well tolerated.

A second phase III trial by the Food and Drug Administration is ongoing. 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).