Most Read Articles
01 Oct 2017
Antidepressants may be effective for treating depression in patients with schizophrenia, according to a meta-analysis that underscores qualifying conclusions based on the small number of low- or moderate-quality studies.
Rachel Soon, 01 Mar 2018

Unregulated online sales of products containing controlled medicines must be curbed in the name of consumer safety, warns the Malaysian Pharmaceutical Society (MPS).

10 Apr 2018
Antiviral treatment for colonic cytomegalovirus (CMV) infection significantly improves short- and long-term surgery-free survival in patients with ulcerative colitis (UC), according to the results of a small-scale study.
Audrey Abella, 03 Oct 2017
Once-monthly and once-quarterly administration of paliperidone palmitate had similar efficacy in terms of relapse prevention for schizophrenia in an East Asian population, according to a subgroup analysis.

Fluorouracil better than imiquimod in short-term prevention of subsequent actinic keratoses

04 Apr 2018

A recent study has shown that 5-fluorouracil is significantly more effective than imiquimod in the short-term prevention of subsequent actinic keratoses (AKs).

Treatment with 5-fluorouracil successfully decreased the incidence of subsequent AKs (cumulative risk difference, –4.54 percent; 95 percent CI, –7.91 to –1.17 percent) in the short term. However, no statistically significant evidence was found with regard to a long-term reduced risk (cumulative risk difference, –1.43 percent; –3.43 to 0.05 percent) compared with that with imiquimod.

This community-based cohort study identified adult health plan members who had an AK diagnosed in 2007 and who subsequently filled a prescription for 5-fluorouracil or imiquimod (n=5,700). The investigators followed participants for subsequent AKs identified by the International Classification of Diseases codes and estimated the short- (2 years) and long-term (5 years) differences in cumulative risk while controlling for potential confounding by pretreatment variables.

“This is a retrospective study with limited ascertainment of all relevant potential confounding variables,” the investigators said.

In an earlier study, Tanghetti and Werschler found that 5-fluorouracil cream twice daily for 2–4 weeks was more effective than imiquimod cream twice weekly for 16 weeks in exposing what were presumed to be subclinical AKs, reducing the final AK count, achieving complete clearance and achieving clearance rapidly. [J Drugs Dermatol 2007;6:144-147]

“Tolerability was similar except for erythema, which was initially significantly higher with 5-fluorouracil than imiquimod but resolved rapidly and was significantly lower than imiquimod by week 16. Five-percent 5-fluorouracil remains the gold standard field therapy for AKs,” Tanghetti and Werschler said.

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Most Read Articles
01 Oct 2017
Antidepressants may be effective for treating depression in patients with schizophrenia, according to a meta-analysis that underscores qualifying conclusions based on the small number of low- or moderate-quality studies.
Rachel Soon, 01 Mar 2018

Unregulated online sales of products containing controlled medicines must be curbed in the name of consumer safety, warns the Malaysian Pharmaceutical Society (MPS).

10 Apr 2018
Antiviral treatment for colonic cytomegalovirus (CMV) infection significantly improves short- and long-term surgery-free survival in patients with ulcerative colitis (UC), according to the results of a small-scale study.
Audrey Abella, 03 Oct 2017
Once-monthly and once-quarterly administration of paliperidone palmitate had similar efficacy in terms of relapse prevention for schizophrenia in an East Asian population, according to a subgroup analysis.