Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

Tristan Manalac, 16 Dec 2017
Methylphenidates, but not amphetamines, when taken during the first trimester of pregnancy, slightly increase the risk of cardiac congenital malformations, a recent study has shown.
06 Feb 2017

The prevalence of benign prostate hypertrophy (BPH) increases with age and is more common in men aged 50 years and above. Dr Ronny Tan, consultant urologist and director of andrology at Tan Tock Seng Hospital, Singapore, speaks on how GPs can best manage this condition.

13 Sep 2018
Long-term treatment with memantine is well tolerated but does not effectively prevent glaucomatous progression in patients with open-angle glaucoma (OAG), according to the results of two phase III trials.

Fluorouracil better than imiquimod in short-term prevention of subsequent actinic keratoses

04 Apr 2018

A recent study has shown that 5-fluorouracil is significantly more effective than imiquimod in the short-term prevention of subsequent actinic keratoses (AKs).

Treatment with 5-fluorouracil successfully decreased the incidence of subsequent AKs (cumulative risk difference, –4.54 percent; 95 percent CI, –7.91 to –1.17 percent) in the short term. However, no statistically significant evidence was found with regard to a long-term reduced risk (cumulative risk difference, –1.43 percent; –3.43 to 0.05 percent) compared with that with imiquimod.

This community-based cohort study identified adult health plan members who had an AK diagnosed in 2007 and who subsequently filled a prescription for 5-fluorouracil or imiquimod (n=5,700). The investigators followed participants for subsequent AKs identified by the International Classification of Diseases codes and estimated the short- (2 years) and long-term (5 years) differences in cumulative risk while controlling for potential confounding by pretreatment variables.

“This is a retrospective study with limited ascertainment of all relevant potential confounding variables,” the investigators said.

In an earlier study, Tanghetti and Werschler found that 5-fluorouracil cream twice daily for 2–4 weeks was more effective than imiquimod cream twice weekly for 16 weeks in exposing what were presumed to be subclinical AKs, reducing the final AK count, achieving complete clearance and achieving clearance rapidly. [J Drugs Dermatol 2007;6:144-147]

“Tolerability was similar except for erythema, which was initially significantly higher with 5-fluorouracil than imiquimod but resolved rapidly and was significantly lower than imiquimod by week 16. Five-percent 5-fluorouracil remains the gold standard field therapy for AKs,” Tanghetti and Werschler said.

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Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

Tristan Manalac, 16 Dec 2017
Methylphenidates, but not amphetamines, when taken during the first trimester of pregnancy, slightly increase the risk of cardiac congenital malformations, a recent study has shown.
06 Feb 2017

The prevalence of benign prostate hypertrophy (BPH) increases with age and is more common in men aged 50 years and above. Dr Ronny Tan, consultant urologist and director of andrology at Tan Tock Seng Hospital, Singapore, speaks on how GPs can best manage this condition.

13 Sep 2018
Long-term treatment with memantine is well tolerated but does not effectively prevent glaucomatous progression in patients with open-angle glaucoma (OAG), according to the results of two phase III trials.