Most Read Articles
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
20 Feb 2019
A recent study has shown that compounded topical pain creams are only as effective as placebo creams in the treatment of localized chronic pain. Their costs are also higher compared with approved compounds, which should discourage routine use.
Audrey Abella, 21 Dec 2018
Use of a single course of the intravenous iron preparation ferumoxytol may lead to sustained improvements in patient-reported outcomes (PROs) of individuals with iron deficiency anaemia (IDA) who had inadequate response to oral iron therapy, according to data presented at ASH 2018.
Saras Ramiya, 23 Oct 2018
The Malaysian Pharmacy Students’ Association (MyPSA) has successfully organized the 13th National Gathering of Pharmacy Students (NoGAPS) in September.

Fluorouracil better than imiquimod in short-term prevention of subsequent actinic keratoses

04 Apr 2018

A recent study has shown that 5-fluorouracil is significantly more effective than imiquimod in the short-term prevention of subsequent actinic keratoses (AKs).

Treatment with 5-fluorouracil successfully decreased the incidence of subsequent AKs (cumulative risk difference, –4.54 percent; 95 percent CI, –7.91 to –1.17 percent) in the short term. However, no statistically significant evidence was found with regard to a long-term reduced risk (cumulative risk difference, –1.43 percent; –3.43 to 0.05 percent) compared with that with imiquimod.

This community-based cohort study identified adult health plan members who had an AK diagnosed in 2007 and who subsequently filled a prescription for 5-fluorouracil or imiquimod (n=5,700). The investigators followed participants for subsequent AKs identified by the International Classification of Diseases codes and estimated the short- (2 years) and long-term (5 years) differences in cumulative risk while controlling for potential confounding by pretreatment variables.

“This is a retrospective study with limited ascertainment of all relevant potential confounding variables,” the investigators said.

In an earlier study, Tanghetti and Werschler found that 5-fluorouracil cream twice daily for 2–4 weeks was more effective than imiquimod cream twice weekly for 16 weeks in exposing what were presumed to be subclinical AKs, reducing the final AK count, achieving complete clearance and achieving clearance rapidly. [J Drugs Dermatol 2007;6:144-147]

“Tolerability was similar except for erythema, which was initially significantly higher with 5-fluorouracil than imiquimod but resolved rapidly and was significantly lower than imiquimod by week 16. Five-percent 5-fluorouracil remains the gold standard field therapy for AKs,” Tanghetti and Werschler said.

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Most Read Articles
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
20 Feb 2019
A recent study has shown that compounded topical pain creams are only as effective as placebo creams in the treatment of localized chronic pain. Their costs are also higher compared with approved compounds, which should discourage routine use.
Audrey Abella, 21 Dec 2018
Use of a single course of the intravenous iron preparation ferumoxytol may lead to sustained improvements in patient-reported outcomes (PROs) of individuals with iron deficiency anaemia (IDA) who had inadequate response to oral iron therapy, according to data presented at ASH 2018.
Saras Ramiya, 23 Oct 2018
The Malaysian Pharmacy Students’ Association (MyPSA) has successfully organized the 13th National Gathering of Pharmacy Students (NoGAPS) in September.