Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 4 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.

FLD may increase risk of atherosclerotic progression in healthy obese individuals

19 Apr 2017
73% of workers aged above 40 were also found to be overweight or obese.

Despite their healthy metabolic profile, metabolically healthy obese (MHO) individuals with fatty liver disease (FLD) are at a higher risk of atherosclerotic progression, a new study shows.

The study involved 1,240 patients (mean age 54.2±7.4 years) who underwent coronary artery calcification (CAC) score measurements during routine check-ups. Those with histories of cardiovascular diseases, taking statins, with hepatocellular carcinoma and who had received liver transplants were excluded.

CAC scores were measured using coronary computed tomography angiography (CCTA) and hepatic ultrasounds. Hepatic ultrasonography was used to potentially diagnose FLD.

Of all participants, 22.7 percent (n=282) had the MHO phenotype. There were more males in the MHO group than in the MH nonobese (MHNO) group. Moreover, individuals in the MHO group had higher levels of low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG) and fasting plasma glucose (FPG).

CAC progression was observed in 25.2 percent (n=312) of participants over the median follow-up period of 2.9 (0.8 to 7.0) years. The metabolically unhealthy obese group (MUO) had the highest proportion of CAC progression (32.3 percent), followed by MHO (28.0 percent), MU nonobese (MUNO; 23.1 percent) and MHNO (19.2 percent).

MHO individuals had an increased risk of CAC progression (unadjusted odds ratio [OR], 1.63; 95 percent CI, 1.15 to 2.32) compared to MHNO individuals. After controlling for confounders, only the MUO had a significantly greater risk of CAC progression (adjusted OR, 1.71; 1.10 to 2.65).

Finally, CAC progression was significantly associated with MHO individuals with FLD at baseline (adjusted OR, 2.37; 1.34 to 4.16) relative to MHNO individuals without baseline FLD. By comparison, MHO individuals without baseline FLD showed no significant association to CAC progression (adjusted OR, 1.26; 0.71 to 2.24).

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Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 4 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.