Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

3 days ago
Waist circumference (WC) trajectories are predictive of altered risk of cardiovascular disease (CVD) among adults, even among those without body mass index (BMI)-defined obesity, a study has shown. Such association appears higher in younger adults.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Flaxseed, hesperidin supplements shine in NAFLD trial

29 Jan 2021

Supplementation with hesperidin and flaxseed leads to better glucose and lipid metabolism, while simultaneously easing inflammation and hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD), a recent study reports.

The randomized, controlled, open-label trial included 100 NAFLD patients, who were assigned to one of four groups: control, 30-g whole flaxseed powder, 1-g hesperidin supplementation, and a combination of both flaxseed and hesperidin. All groups also participated in a lifestyle modification programme. Outcomes included changes in anthropometric measurements, glucose and lipid profiles, inflammatory markers, hepatic steatosis, and fibrosis.

After 12 weeks of intervention, hepatic steatosis dropped by at least 40 percent in all three intervention, groups, as opposed to the 22-percent reduction in controls. Similarly, the number of patients with normal liver fat content was highest in the combination intervention (n=9) and lowest in controls (n=2); among-group difference was not significant (p=0.149).

All intervention groups also saw improvements in liver function biomarkers, with significant changes in alanine aminotransferase and gamma-glutamyl transferase by the end of the trial. Liver fat content also dropped to a greater extent when lifestyle modification was combined with either or both supplements. Flaxseed, alone or when used with hesperidin, significantly reduced liver fibrosis.

The researchers also found significant beneficial effects of the test supplements on other factors such as blood glucose, insulin, insulin resistance, triglycerides, total cholesterol, high-sensitivity C-reactive protein, and tumour necrosis factor α.

“In the current study, we assessed the superiority of two dietary supplements to common lifestyle modifications in NAFLD management,” the researchers said. “The results showed that taking hesperidin or flaxseed or a combination can increase the effectiveness of lifestyle modifications in NAFLD management.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

3 days ago
Waist circumference (WC) trajectories are predictive of altered risk of cardiovascular disease (CVD) among adults, even among those without body mass index (BMI)-defined obesity, a study has shown. Such association appears higher in younger adults.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.