Fish, egg intake may prevent success of H. pylori eradication therapy
High consumption of fish and egg appears to be negatively associated with successful Helicobacter pylori eradication therapy in H. pylori‒positive patients with gastritis and/or duodenal ulcers, a recent study has found.
Researchers examined the influence of food and nutrient intake on H. pylori eradication therapy in 4,014 participants who underwent endoscopy, were tested for serum antibodies to H. pylori (2,046 positive; 51.0 percent) and had their food intake assessed using a food-frequency questionnaire (FFQ).
Among those who tested positive, endoscopies showed gastritis and/or duodenal ulcers in a total of 389 patients (19.0 percent), who also tested positive for a 13C-urea breath test (UBT). The said patients were given 1-week H. pylori eradication treatment with lansoprazole, amoxicillin and clarithromycin and a second UBT 8 weeks after treatment.
Of these patients, 352 had complete demographic characteristics, serum lipid, insulin, glycated haemoglobin, C-reactive protein (CRP) and creatinine concentrations, as well as complete FFQs. Researchers used multivariate logistic regression analysis to determine factors correlated with successful H. pylori eradication therapy.
Overall, there was a 60.4-percent (235 of 389) success rate of H. pylori eradication therapy.
The factors associated with treatment failure were as follows: increased age (p=0.02), higher CRP concentration (p<0.01), higher dietary cholesterol (p<0.01) or egg intake (p<0.01), higher ω-3 (n–3) fatty acid (p=0.02) or fish intake (p=0.01), and higher vitamin D intake (p=0.02). In addition, a strong association existed between higher vitamin D intake and higher fish consumption.
This study was limited by the failure to investigate the antibiotic resistance of H. pylori, researchers said.