Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 20 Apr 2018
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6 days ago
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Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.

Fidaxomicin therapy most effective during first episode of C. difficile infection

14 Jan 2018

Patients with a first episode of Clostridium difficile infection (CDI) are likely to respond to treatment with fidaxomicin with no recurrences, a recent study has shown. On the other hand, those with prior CDI episodes are less likely to respond, especially with >1 prior episode, and more likely to recur, which suggests a greater clinical benefit of fidaxomicin earlier in the course of CDI.

There were 81 patients (median age 55.9 years; 53 percent female; 26 percent with inflammatory bowel disease) included in the study, of which 90 percent responded to fidaxomicin therapy. Prior CDI episodes were fewer (p=0.01) in responders (median, 1; range, 0‒8) vs nonresponders (median, 2.5; range, 1‒8). Response was 100 percent after a first CDI episode, 96 percent after one prior episode, and 82 percent after two or more (p=0.02).

There was a 19-percent recurrence rate. Patients who did not recur had fewer prior episodes of CDI (median 1; range 0‒6) than those with a recurrence (median, 2; range, 1‒8; p=0.005). Recurrence was 0 percent after a first episode, 23 percent after one prior episode, and 29 percent after two or more (p=0.005).

All patients with inflammatory bowel disease, as a response, either improved their symptoms or had a negative C. difficile test. Recurrence occurred in 19 percent.

The investigators included all CDI cases treated with fidaxomicin at three referral centres over a 4-year period. The definition of ‘response’ was resolution of diarrhoea, and ‘recurrence’ was defined by CDI recurrence within 8 weeks of the end of treatment.

“Fidaxomicin is a new antibiotic used to treat CDI,” according to the investigators. 

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 20 Apr 2018
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
6 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 4 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.