Most Read Articles
Pearl Toh, 5 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 3 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.

Fibrosis predicts T2DM, AHT in metabolically healthy NAFLD patients

4 days ago

Healthy patients with significant fibrosis related to nonalcoholic fatty liver disease (NAFLD) are at a higher risk of developing type 2 diabetes mellitus (T2DM) and arterial hypertension (AHT), a recent study has shown.

The study included 178 patients (mean age, 44.5±12 years; 56 percent male) with biopsy-proven NAFLD, but who were metabolically healthy, as defined by a baseline absence of T2DM, AHT, and dyslipidaemia. Fibrosis measures included the Hepamet Fibrosis Score (HFS), NAFLD Fibrosis Score, and FIB-4. Outcomes were changes in metabolic health.

Patients were followed for an average of 5.6±4.4 years, during which time nine percent (n=16) developed T2DM and 8.4 percent (n=15) developed AHT. Low high-density lipoprotein levels were reported in 9.6 percent (n=17), while hypertriglyceridemia was observed in 23.6 percent (n=42). Only one death was reported.

T2DM occurred significantly more commonly among patients with significant vs mild fibrosis (17.1 percent vs 7 percent; p=0.006). This was further confirmed by multivariate analysis, which found that significant fibrosis increased the risk of T2DM (hazard ratio [HR], 2.95, 95 percent confidence interval [CI], 1.19–7.31; p=0.019).

Similar patterns were observed with AHT, which occurred more frequently in those with significant fibrosis (17.1 percent vs 6.3 percent; p=0.005). In turn, significant fibrosis emerged as an important risk factor for AHT (HR, 2.39, 95 percent CI, 1.14–5.10; p=0.028).

Other important risk factors for both metabolic outcomes included age, body mass index, and glucose concentration.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Hepatology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 5 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 3 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.