Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

4 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
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Fewer lactobacilli in guts of male infants born to asthmatic mothers

07 Dec 2017

Lactobacilli bacteria appear to be less abundant in the guts of male infants born to asthmatic mothers, a recent study shows. On the other hand, Bacteroidaceae are more abundant in the guts of female infants.

The study included 1,021 mother-infant pairs recruited, from whom infant faecal samples were collected at 3 to 4 months of age. Relative microbial abundance and diversity was determined using sequencing of the 16s rRNA gene.

Maternal asthma status and medication during pregnancy were self-reported through standardized questionnaires.

Of all the infants, 9 percent were born to mothers who had asthma during pregnancy. The gut microbiota of the entire cohort was dominated by members of the Proteobacteria, Firmicutes and Bacteroidetes phyla. The guts of females had more Bacteroidetes than males (20.8 vs 9.3 percent).

The median relative abundance of Bacteroidetes was significantly higher in female infants born to mothers with asthma and concomitant allergies during pregnancy (p=0.02). The same trend was observed for members of the Bacteroidaceae family (p=0.03) and Megasphaera genus (p=0.02).

By comparison, males born to asthmatic mothers with concomitant allergies had borderline significant lower abundance of the Enterobacteriaceae (p=0.05) family and significantly higher abundance of the Lactobacillaceae family (p=0.03) and Megasphaera genus (p=0.03).

In multivariable regression analysis, infants born to mothers with prenatal asthma were significantly less likely to have high abundances of Lactobacillus bacteria (adjusted odds ratio [OR], 0.36; 95 percent CI, 0.16 to 0.78; p=0.01). This trend was preserved in males (adjusted OR, 0.26; 0.07 to 0.89; p=0.03) but not in females (adjusted OR, 0.48; 0.17 to 1.32; p=0.16).

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Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

4 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
4 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.