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Fertility treatment bears no excess breast cancer risk for BRCA1/2 mutation carriers

6 days ago

Among women carrying BRCA1/2 mutation, the use of fertility treatment does not contribute to a discernible increase in breast cancer risk, according to a study.

The analysis included a total of 1,824 Jewish Israeli women with confirmed BRCA1/2 mutation, among whom 332 (18.2 percent) had undergone fertility treatment with clomiphene citrate (n=134), gonadotropin (n=119), in vitro fertilization (n=183), or a combination of treatments (n=89). The remaining 1,492 (81.8 percent) women had not been treated for infertility.

Breast cancer was diagnosed in 687 women overall. Multivariable Cox proportional hazards analysis showed no link between fertility treatment and breast cancer risk in the overall population and when stratified by each gene.

The corresponding hazard ratios (HRs) for breast cancer were 0.77 (95 percent confidence interval [CI], 0.49–1.19) with clomiphene citrate, 0.54 (95 percent CI, 0.28–1.01) with gonadotropin, 0.65 (95 percent CI, 0.39–1.08) with in vitro fertilization, and 1.23 (95 percent CI, 0.49–3.06) with combined treatments.

Meanwhile, paternal origin of the mutation conferred a risk increase (HR, 1.43, 95 percent CI, 1.17–1.75), as did the long-term use of oral contraceptives (>5 years vs nonuse: HR, 1.62, 95 percent CI, 1.27–2.06), in both BRCA1 and BRCA2 mutation carriers.

Finally, women using any oral contraceptives were at lower risk of ovarian cancer (HR, 0.61, 95 percent CI, 0.46–0.82).

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Most Read Articles
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Pearl Toh, 19 Mar 2021
Dupilumab effectively prevents severe asthma exacerbations and improves lung function in patients with difficult-to-treat type 2 asthma, according to a post hoc analysis of the LIBERTY ASTHMA QUEST study presented at AAAAI 2021.
Elaine Soliven, 17 Mar 2021
Treatment with an intranasal budesonide aqueous spray led to significantly reduced nasal symptoms in adults with rhinitis exposed to high levels of airborne pollution, according to a study presented at AAAAI 2021.