Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Fertility therapy may increase risk of stroke

05 Sep 2017

The long-term cardiovascular (CV) safety of fertility therapy, particularly stroke, remains unclear due to the small number of studies and significant heterogeneity in this systematic review and meta-analysis.

The investigators searched published reports for studies addressing the question “does fertility therapy increase the risk of longer-term cardiovascular outcomes?” to summarize information linking fertility therapy with subsequent CV outcomes. They included 1) human studies; 2) case-control, cohort or randomized designs with 3) exposure to fertility therapy and 4) CV outcomes clearly reported; 5) presence of comparison group; 6) minimum 1-year follow-up; and 7) adjustment for age.

DerSimonian and Laird random-effects models were used to pool hazard ratios (HRs) with 95 percent confidence intervals (CIs) of outcomes such as acute cardiac event, stroke, venous thromboembolism, hypertension and diabetes mellitus, comparing women who received fertility therapy with those who did not.

A total of six observational studies were included in the meta-analysis, involving 41,910 women who received fertility therapy and 1,400,202 women who did not.

The meta-analysis showed no increased risk of a cardiac event (pooled HR, 0.91; 95 percent CI, 0.67 to 1.25; I2=36.6 percent) or diabetes mellitus (pooled HR, 0.93; 0.87 to 1.001; I2=0 percent). There were no pooled results for hypertension (I2=95.0 percent) and venous thromboembolism (I2=82.3 percent). On the other hand, a trend toward higher risk of stroke (pooled HR, 1.25; 0.96 to 1.63; I2=0 percent) was observed.

“Future studies are needed to address ongoing knowledge gaps in this area,” researchers said.

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.