Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
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Fertility therapy may increase risk of stroke

05 Sep 2017

The long-term cardiovascular (CV) safety of fertility therapy, particularly stroke, remains unclear due to the small number of studies and significant heterogeneity in this systematic review and meta-analysis.

The investigators searched published reports for studies addressing the question “does fertility therapy increase the risk of longer-term cardiovascular outcomes?” to summarize information linking fertility therapy with subsequent CV outcomes. They included 1) human studies; 2) case-control, cohort or randomized designs with 3) exposure to fertility therapy and 4) CV outcomes clearly reported; 5) presence of comparison group; 6) minimum 1-year follow-up; and 7) adjustment for age.

DerSimonian and Laird random-effects models were used to pool hazard ratios (HRs) with 95 percent confidence intervals (CIs) of outcomes such as acute cardiac event, stroke, venous thromboembolism, hypertension and diabetes mellitus, comparing women who received fertility therapy with those who did not.

A total of six observational studies were included in the meta-analysis, involving 41,910 women who received fertility therapy and 1,400,202 women who did not.

The meta-analysis showed no increased risk of a cardiac event (pooled HR, 0.91; 95 percent CI, 0.67 to 1.25; I2=36.6 percent) or diabetes mellitus (pooled HR, 0.93; 0.87 to 1.001; I2=0 percent). There were no pooled results for hypertension (I2=95.0 percent) and venous thromboembolism (I2=82.3 percent). On the other hand, a trend toward higher risk of stroke (pooled HR, 1.25; 0.96 to 1.63; I2=0 percent) was observed.

“Future studies are needed to address ongoing knowledge gaps in this area,” researchers said.

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Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.