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Females with vitreoretinal diseases show increased estradiol levels in vitreous body

21 Jul 2017

Females with vitreoretinal diseases have significantly elevated levels of estradiol (E2) in the vitreous body compared with the serum, reveals a new study.

E2 measurements were collected from 71 patients with the following vitreoretinal diseases: idiopathic epiretinal membrane (ERM; 3 males, 11 females), idiopathic macular hole (MH; 3 males, 15 females), proliferative diabetic retinopathy (PDR; 10 males, 10 females) and rhegmatogenous retinal detachment (RD; 3 males, 16 females).

Mean E2 concentrations across all diseases in the serum and vitreous body in males were 27.53±7.47 and 6.47±5.72 pg/mL, respectively. In females, corresponding concentrations were 8.33±6.62 and 16.83±5.37 pg/mL.

Males had significantly higher E2 levels in the serum than in the vitreous body, while females had significantly greater E2 concentrations in the vitreous body (p<0.001).

Testosterone (T) measurements were also collected from 61 patients with one of the four vitreoretinal diseases: ERM (12 males, 2 females), MH (2 males, 15 females), PDR (9 males, 4 females) and RD (6 males, 11 females).

Across all four diseases, mean T concentrations in the male vitreous body and serum were 0.15±0.02 and 4.70±1.69 ng/mL, respectively, yielding a statistically significant difference (p<0.001). Corresponding values in females were 0.15±0.05 and 0.17±0.08 ng/mL, respectively.

Vitreous fluid samples were collected during vitreous surgery and subjected to electro-chemiluminescence immunoassay to measure hormone levels. Paired T-tests were used to quantify significant differences.

Future studies should focus on identifying the cells that produce E2 and T and the production of aromatase in the eye, both of which may explain the gender differences in E2 levels, according to researchers.

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.