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Females with past pre-eclampsia have higher CIMT

21 Sep 2017
The study reaffirms that low-dose aspirin can be considered as a prophylactic of preterm delivery for women at high risk of preeclampsia

Carotid artery intima-media thickness (CIMT) is significantly higher in females with histories of pre-eclampsia, a recent study has found.

The study included 80 females, of which 40 had histories of pre-eclampsia (mean age at first birth 24.2±3.7 years) while the other 40 had normotensive pregnancies (mean age at first birth 24.3±3.4 years).

CIMT was significantly higher in participants with histories of pre-eclampsia than in those who have had normotensive pregnancies (median thickness 0.80 [0.75 to 0.85] vs 0.73 [0.70 to 0.78] mm; p=0.004). Hypertension (p<0.001) was significantly more common and insulin (p<0.001) was higher in those with histories of pre-eclampsia.

Ordinal logistic models showed that the likelihood of having CIMT values higher than thresholds were significantly higher in females with histories of pre-eclampsia than in normotensive participants (odds ratio [OR], 3.33; 95 percent CI, 1.50 to 7.39; p=0.003).

This statistically significant relationship remained even after adjusting for age, hypertension, dyslipidaemia, body mass index and homeostatic model assessment for insulin resistance scores (HOMA-IR; OR, 3.31; 1.32 to 8.27; p=0.01).

A subsequent meta-analysis of 10 studies showed that even at 10 years postpartum, CIMT was significantly higher in those with histories of pre-eclampsia (standardized mean difference [SMD], 0.18; 0.05 to 0.30; p=0.004).

Restricting the analysis to exclude those with chronic hypertension during pregnancy (n=5; SMD, 0.27; 0.08 to 0.46; p=0.005) or include only those above 50 years of age (SMD, 0.27; 0.05 to 0.50; p=0.02) did not attenuate the significant effect of pre-eclampsia on CIMT.

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Most Read Articles
Roshini Claire Anthony, Yesterday

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
17 May 2018
A study examining the validity of baseline cardiac screening for left ventricular ejection fraction (EF) has found that only two (1.1 percent) of the screened patients have an abnormal EF (<50 percent). These patients have received doxorubicin (anthracycline) chemotherapy despite a compromised EF.
Yesterday
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