Most Read Articles
Rachel Soon, Yesterday

Guidelines for local pharmacists on what actions to take during the COVID-19 pandemic have been issued by the Malaysian Pharmaceutical Society (MPS).

Elvira Manzano, 22 Nov 2017
A blood pressure (BP) reading of 130/80 mm Hg or higher is the ‘new high’ in the latest AHA/ACC* hypertension guidelines, a threshold that is tighter than the JNC 7** cutpoint of 140/90 mm Hg for stage 1 hypertension in the general population. The change will mean more patients being labelled with hypertension.
02 Apr 2020
Cabozantinib plus androgen deprivation therapy (ADT) shows potent clinical activity in hormone-naïve metastatic prostate cancer (HNMPCa), according to the results of a phase II trial.
Roshini Claire Anthony, 6 days ago

The effect of various antihypertension medications on reducing cardiovascular (CV) risk may differ across drug classes, according to a meta-analysis.

Female gender, dosage predict gastrin elevation in GERD patients on long-term PPI therapy

13 Feb 2020

Dosage and female gender are associated with the development of gastrin elevation following proton pump inhibitor (PPI) therapy, a recent study has found. Moreover, fasting serum gastrin significantly correlates with PPI dosage over weight and over body surface area.

This cross-sectional study sought to determine the most important predictors for gastrin elevation in patients on long-term PPI therapy through analysis of data from two published studies in Icelandic patients with endoscopically verified erosive gastro-oesophageal reflux disease (GERD).

The investigators compared PPI exposure in dosage over weight (mg/kg) and dosage over body surface area (mg/m2) with fasting gastrin levels in two separate multiple linear regression models. They also obtained data on age, gender, weight, smoking, H. pylori infection, and PPI duration and type.

Analysis was conducted in 157 patients (78 females). Females had significantly higher median serum gastrin levels than males (92 vs 60 pg/mL; p=0.001). In simple linear regression, serum gastrin levels was associated with gender (p=0.0008) and PPI exposure in mg/kg (p=0.0001) and mg/m2 (p=0.0001).

In multiple linear regression, higher gastrin values were predicted by PPI exposure, both in mg/kg (β, 0.95, 95 percent confidence interval [CI], 0.4–1.5; p=0.001) and mg/m2 (β, 0.02, 95 percent CI, 0.0–0.0; p=0.0015) and female gender (β, 0.2, 95 percent CI, 0.0–0.4; p=0.02).

“Gastrin elevation is a known but variable consequence of PPI therapy,” the investigators noted. “Concerns have been raised about the clinical importance of chronic PPI induced gastrin elevation.”

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Most Read Articles
Rachel Soon, Yesterday

Guidelines for local pharmacists on what actions to take during the COVID-19 pandemic have been issued by the Malaysian Pharmaceutical Society (MPS).

Elvira Manzano, 22 Nov 2017
A blood pressure (BP) reading of 130/80 mm Hg or higher is the ‘new high’ in the latest AHA/ACC* hypertension guidelines, a threshold that is tighter than the JNC 7** cutpoint of 140/90 mm Hg for stage 1 hypertension in the general population. The change will mean more patients being labelled with hypertension.
02 Apr 2020
Cabozantinib plus androgen deprivation therapy (ADT) shows potent clinical activity in hormone-naïve metastatic prostate cancer (HNMPCa), according to the results of a phase II trial.
Roshini Claire Anthony, 6 days ago

The effect of various antihypertension medications on reducing cardiovascular (CV) risk may differ across drug classes, according to a meta-analysis.