Most Read Articles
Pearl Toh, 08 Jan 2021
Combining the anti-PD-1 antibody sintilimab and a bevacizumab biosimilar significantly improves survival compared with the standard treatment of sorafenib in the first-line setting for patients with advanced, unresectable hepatocellular carcinoma (HCC), according to the ORIENT-32 study presented at ESMO Asia 2020.
Dr Margaret Shi, 15 Jan 2021

Cancer patients at are an increased risk of severe coronavirus disease 2019 (COVID-19) and should be positioned at high priority for vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) regardless of age, according to statements issued by the European Society for Medical Oncology (ESMO).

Fear of falling has multifactorial roots in elderly adults with cancer

29 Apr 2020

Several mental and physical factors, including cognitive status and prior falls, contribute to the fear of falling (FOF) among elderly adults with cancer, a recent study has found.

Accessing the International Mobility in Ageing Study, researchers identified 175 elderly adults (mean age, 69.3 years; 50.2 percent female) who self-identified as cancer patients. The primary outcome was FOF, as measured by the Falls Efficacy Scale-International (FES-I). A parallel group of 177 healthy, age-matched participants was also enrolled.

In cancer patients, FOF varied significantly according to clinical variables. In particular, FES-I scores were higher among patients with a high burden of depressive symptoms, poor physical performance status and a history of falls in the prior year.

Multiple linear regression analysis confirmed that depressive symptoms, as measured by the Centre of Epidemiological Studies-Depression tool, was a risk factor for FOF with borderline significance (estimate, 0.16; p=0.09). In comparison, the number of falls in the last 12 months was able to significantly predict FOF (estimate, 0.93; p=0.01).

On the other hand, global cognition, as measured by the Leganes Cognitive Test (estimate, –1.35; p=0.00), and physical performance (estimate, –2.23; p<0.0001) were both significantly but negatively correlated with FOF.

“This study found that FOF is multifactorial in people with cancer,” the researchers said. “Recognizing and designing an intervention that targets these factors would help in reducing the impact of FOF in people with cancer.”

“This study lays the groundwork for future studies of cancer and FOF that include a broader range of risk factors,” they added.

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Most Read Articles
Pearl Toh, 08 Jan 2021
Combining the anti-PD-1 antibody sintilimab and a bevacizumab biosimilar significantly improves survival compared with the standard treatment of sorafenib in the first-line setting for patients with advanced, unresectable hepatocellular carcinoma (HCC), according to the ORIENT-32 study presented at ESMO Asia 2020.
Dr Margaret Shi, 15 Jan 2021

Cancer patients at are an increased risk of severe coronavirus disease 2019 (COVID-19) and should be positioned at high priority for vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) regardless of age, according to statements issued by the European Society for Medical Oncology (ESMO).