Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 3 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 4 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.

Fatty acid desaturase variants tied to gestation duration

6 days ago

An association exists between fatty acid desaturase (FADS) variants and gestation duration, suggesting that long-chain polyunsaturated fatty acids (LC-PUFAs) may play a potential role in gestation duration, reports a study that utilizes a Mendelian randomization approach.

The investigators genotyped 35 genetic variants in FADS1, FADS2 and FADS3 in 898 mothers and 1,103 offspring as part of a triethnic mother-offspring cohort in Singapore, as well as measured maternal plasma n–3 and n–6 PUFA concentrations at 26–28 weeks of gestation. An ultrasound dating scan in early pregnancy and from birth date was used to obtain gestation duration. Birth length and weight were also measured.

The investigators selected eight FADS variants through a tagging-SNP approach and examined these in association with PUFA concentration, gestation duration among spontaneous labours, and birth size using ethnicity-adjusted linear regressions and survival models that accounted for the competing risks of induced labour and prelabour caesarean delivery.

Tagging for eight other variants located on FADS1 and FADS2, maternal FADS1 variant rs174546 was strongly associated with plasma n–6 but not n–3 LC-PUFA concentrations. Among women who had spontaneous labour, offspring and maternal FADS3 variants correlated with gestation duration. Each copy of rs174450 minor allele C correlated with a shorter gestation by 2.2 days (95 percent CI, 0.9–3.4) for maternal variants and 1.9 days (0.7–3.0) for offspring variants.

Survival models showed that rs174450 minor vs major allele homozygotes had reduced time to delivery after spontaneous labour (mothers: hazard ratio [HR], 1.51; 1.18–1.95; offspring: HR, 1.51; 1.20–1.89).

“In randomized trials, supplementation of n–3 LC-PUFAs during pregnancy has resulted in increased size at birth, which is attributable to longer gestation,” the investigators noted.

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Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 3 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 4 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.