Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Fatigue common in early rheumatoid arthritis

27 Dec 2020

Many patients with early rheumatoid arthritis (RA) experience fatigue, which is associated with pain, a study has found.

The analysis included 1,864 patients (mean age, 54.5 years; 71.8 percent female) who reported fatigue at baseline. Fatigue was low in 23 percent of patients, moderate in 19 percent, and severe in 59 percent. At baseline, mean fatigue numerical rating scale (NRS) was 5.1, while that of pain was 5.4; mean pain scores markedly differed among the three fatigue levels.

Mean Disease Activity Score in 28 joints (DAS28) at baseline was 4.86, with all fatigue groups having scores consistent with moderate disease activity although still different among the three fatigue levels. Median erythrocyte sedimentation rate (ESR) at baseline was 20.0 mm/hr, while median C-reactive protein (CRP) level was 6.7 mg/L. There were 38 patients (2 percent) with fibromyalgia, 227 (12 percent) with osteoarthritis, and 184 (10 percent) with depression.

Fatigue showed a significant association with pain and patient global disease activity ratings (p<0.001), as well as a weak correlation with the DAS28, tender joint count, swollen joint count, physician global assessment of disease activity, ESR, and CRP.

At 3 months, patients who reported low fatigue had significantly lower fatigue compared with those who had moderate or high fatigue (p<0.001), as did those patients who achieved a DAS28 ≤3.2 vs >3.2 (p<0.001). The improvements in fatigue persisted through 5 years of follow‐up. Maximal improvements in fatigue lagged behind remission by 6 months.

Early treatment response within 3 months after treatment initiation was associated with short‐term and long‐term improvements in fatigue over time.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.