Most Read Articles
15 Jan 2018
Body surface area (BSA) affected by psoriasis can be measured to target diabetes prevention efforts for patients with psoriasis, a recent study suggests.
Pearl Toh, 14 Apr 2018
Taking the oral extract product of the fern Polypodium leucotomos (PLE) on top of the standard topical hydroquinone cream and sunscreen reduces the severity of melasma to a greater extent compared with the standard treatment alone in Asian patients, a pilot study has shown.
Jan Welch, 01 Jun 2011

Sexually transmitted infections (STIs) are common, with rates of many infections increas­ing over the last two decades.1 Community screening studies in the UK have shown a prevalence of about 10% for chlamydial infection2 and (among women screened in an urban setting) 3% for gonorrhoea.3 In women (Figure 1), these potentially serious infections are often asymptomatic, whereas the presence of symptoms such as vaginal discharge generally indicates a less pathogenic (but still potentially debilitating) infection, with an organism such as Candida. STIs are often multiple, and the finding of one infection should prompt consider­ation of testing for others. Many sexual health services now initially provide screening tests for asymptomatic women, but a more comprehensive assessment—comprising detailed history4 and genital examination5—is usually necessary when symptoms are present.

Stephen Padilla, 5 days ago
High use of hydrochlorothiazide (HCTZ) appears to significantly increase the risk of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), suggests a recent study. Use of other diuretic and antihypertensive medications does not appear to be linked to NMSC.

Fatigue, poor quality of life, depression hallmarks of post-treatment Lyme disease syndrome

06 Feb 2018
The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Clinically significant fatigue, musculoskeletal pain, sleep disturbance and depression are common in patients with post-treatment Lyme disease syndrome (PTLDS), a recent US study has shown.

The study included 61 patients with defined PTLDS (mean age 49.3 years; 52.5 percent female) and 26 healthy controls (mean age 54.7 years; 53.9 percent female) without a history of Lyme disease. Self-reported fatigue was significantly higher in the PTLDS patients relative to controls, according to the Fatigue Severity Scale (50.0±10.6 vs 19.8±8.6 points; p<0.001).

In the Short-Form McGill Pain Questionnaire, PTLDS patients were found to have significantly worse pain than controls (13.7±8.3 vs 0.8±1.9 points; p<0.001). Depression was likewise significantly worse in PTLDS patients, as per the Beck Depression Inventory (15.1±7.7 vs 2.2±3.2 points; p<0.001).

Moreover, the proportion of participants reporting symptom severity above the clinically relevant cutoffs were significantly higher in the PTLDS vs control group for fatigue (86.9 percent vs 7.7 percent), sleep quality (79.3 percent vs 26.9 percent) and depression (50.0 percent vs 0.0 percent; p<0.001 for all).

Quality of life was also poorer for PTLDS patients, who scored significantly lower on the physical component score part of the Short-Form Health Survey than the population mean (p<0.001). Mental component scores were also significantly lower among PTLDS patients (p<0.001).

The current findings indicated that while physical and clinical laboratory tests showed few abnormalities that could be used to identify PTLDS patients, “standardized questionnaires revealed that these patients are highly symptomatic, with clinically significantly poorer quality of life compared both to healthy controls and the US population,” researchers said.

Editor's Recommendations
Most Read Articles
15 Jan 2018
Body surface area (BSA) affected by psoriasis can be measured to target diabetes prevention efforts for patients with psoriasis, a recent study suggests.
Pearl Toh, 14 Apr 2018
Taking the oral extract product of the fern Polypodium leucotomos (PLE) on top of the standard topical hydroquinone cream and sunscreen reduces the severity of melasma to a greater extent compared with the standard treatment alone in Asian patients, a pilot study has shown.
Jan Welch, 01 Jun 2011

Sexually transmitted infections (STIs) are common, with rates of many infections increas­ing over the last two decades.1 Community screening studies in the UK have shown a prevalence of about 10% for chlamydial infection2 and (among women screened in an urban setting) 3% for gonorrhoea.3 In women (Figure 1), these potentially serious infections are often asymptomatic, whereas the presence of symptoms such as vaginal discharge generally indicates a less pathogenic (but still potentially debilitating) infection, with an organism such as Candida. STIs are often multiple, and the finding of one infection should prompt consider­ation of testing for others. Many sexual health services now initially provide screening tests for asymptomatic women, but a more comprehensive assessment—comprising detailed history4 and genital examination5—is usually necessary when symptoms are present.

Stephen Padilla, 5 days ago
High use of hydrochlorothiazide (HCTZ) appears to significantly increase the risk of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), suggests a recent study. Use of other diuretic and antihypertensive medications does not appear to be linked to NMSC.