Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.

Family history of aortic dissection ups risk of disorder, surgery

10 Sep 2020

Individuals with a family history of aortic dissection (AD) are at high risk of developing AD and undergoing later aortic surgery than those with no family history, reveals a study.

The authors used the Taiwan National Health Insurance database to conduct both cross-sectional and cohort studies. They also used a registry parent–offspring relationship algorithm to reconstruct the genealogy of this population for heritability estimation. A total of 23,868 patients with an AD diagnosis in 2015 were included in the cross-sectional study.

The prevalence and adjusted relative risks (RRs) were assessed. The liability threshold model was used to examine the effects of heritability and environmental factors. To compare late outcomes in the cohort study, a 1:10 propensity score–matched cohort comprising AD patients with or without a family history of AD was included.

A family history of AD in first-degree relatives resulted in an RR of 6.82 (95 percent confidence interval [CI], 5.12–9.07). AD heritability was estimated to be 57.0 percent for genetic factors, 3.1 percent for shared environmental factors, and 40.0 percent for nonshared environmental factors.

Analysis excluding those with Marfan syndrome or bicuspid aortic valve revealed the association of a family history of AD with an RR of 6.56 (95 percent CI, 4.92–8.77) for AD. Patients with AD and a family history of AD also had a higher risk of later aortic surgery compared to those with AD without a family history (subdistribution hazard ratio, 1.40, 95 percent CI, 1.12–1.76).

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.