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Family history affects cardiometabolic risk among men with erectile dysfunction

12 Dec 2020
Sexual health in men – supplements vs medication

Among men with erectile dysfunction (ED), family history (FH) of cardiometabolic factors appears to be linked with a poorer metabolic profile and may be used to improve cardiovascular (CV) risk stratification, a recent study has shown.

The study included 4,693 men with ED (mean age, 51.3±13.3 years) attending an andrology outpatient clinic. FH was determined through interviews. Outcomes included metabolic and sexual function parameters, including blood chemistry and anthropometry.

Of the participants, 28.7 percent (n=1,348) had FH for diabetes mellitus, 27.7 percent (n=1,299) for hypertension, 26.9 percent (n=1,264) for coronary artery disease, 9.7 percent (n=457) for stroke or transient ischaemic attack (TIA), and 2.1 percent (n=99) for peripheral arterial disease. Most either had no (38.9 percent) or one (34.7 percent) FH factors, while only 0.9 percent had ≥4 such factors.

After adjusting for age, the researchers found that having more FH factors was correlated with greater waist circumference, and higher blood glucose and glycated haemoglobin levels. Diastolic, but not systolic, blood pressure also spiked with more FH factors. On the other hand, high-density lipoprotein cholesterol dropped with increasing FH.

Further adjusting for the Chronic Disease Score, a higher number of FH factors was confirmed as a significant correlate of the number of metabolic syndrome components (p<0.0001).

A similar effect was reported for sexual function parameters, with greater FH factors correlating with a higher risk of moderate-to-severe ED.

A subset of 1,595 participants were followed after a mean of 4.2±2.5 years. Over this time period, a total of 136 major adverse cardiovascular events (MACE) occurred, most of which were of ischaemic heart disease (64.0 percent) or stroke/TIA (26.5 percent). Cox regression found that men with at least one FH parameter were significantly more at risk of MACEs (p=0.023).

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Most Read Articles
08 Apr 2021
While early-phase clinical trials may demonstrate substantial levels of overall response rates in patients with relapsed/refractory multiple myeloma (RRMM), high heterogeneity of evidence prevents the accurate assessment of clinical benefit before patient participation, reports a recent meta-analysis.
Elvira Manzano, 28 Mar 2021
The COVID-19 vaccine AZD1222 by AstraZeneca and the University of Oxford was 79 percent effective overall in preventing symptomatic infections – higher than observed in previous clinical trials of the vaccine – at the interim analysis of a US phase III trial.
6 days ago
The chances of a live birth following either fresh or frozen-thawed embryo transfer cycles cannot be predicted by endometrial thickness alone, according to a study.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.