Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Family history affects cardiometabolic risk among men with erectile dysfunction

12 Dec 2020
Sexual health in men – supplements vs medication

Among men with erectile dysfunction (ED), family history (FH) of cardiometabolic factors appears to be linked with a poorer metabolic profile and may be used to improve cardiovascular (CV) risk stratification, a recent study has shown.

The study included 4,693 men with ED (mean age, 51.3±13.3 years) attending an andrology outpatient clinic. FH was determined through interviews. Outcomes included metabolic and sexual function parameters, including blood chemistry and anthropometry.

Of the participants, 28.7 percent (n=1,348) had FH for diabetes mellitus, 27.7 percent (n=1,299) for hypertension, 26.9 percent (n=1,264) for coronary artery disease, 9.7 percent (n=457) for stroke or transient ischaemic attack (TIA), and 2.1 percent (n=99) for peripheral arterial disease. Most either had no (38.9 percent) or one (34.7 percent) FH factors, while only 0.9 percent had ≥4 such factors.

After adjusting for age, the researchers found that having more FH factors was correlated with greater waist circumference, and higher blood glucose and glycated haemoglobin levels. Diastolic, but not systolic, blood pressure also spiked with more FH factors. On the other hand, high-density lipoprotein cholesterol dropped with increasing FH.

Further adjusting for the Chronic Disease Score, a higher number of FH factors was confirmed as a significant correlate of the number of metabolic syndrome components (p<0.0001).

A similar effect was reported for sexual function parameters, with greater FH factors correlating with a higher risk of moderate-to-severe ED.

A subset of 1,595 participants were followed after a mean of 4.2±2.5 years. Over this time period, a total of 136 major adverse cardiovascular events (MACE) occurred, most of which were of ischaemic heart disease (64.0 percent) or stroke/TIA (26.5 percent). Cox regression found that men with at least one FH parameter were significantly more at risk of MACEs (p=0.023).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.