Most Read Articles
Natalia Reoutova, 2 days ago

Patients with coronavirus disease 2019 (COVID-19) who have haematologic malignancies have a 28 percent mortality rate, according to data collected from 250 patients by the ASH Research Collaborative COVID-19 presented at the 62nd American Society of Hematology Annual Meeting and Exposition (ASH 2020).

Roshini Claire Anthony, 01 Dec 2020

An evidence-based, multifaceted intervention aimed at reducing haemodialysis catheter-related bloodstream infections (HD-CRBSIs) failed to improve this outcome, results of the REDUCCTION* trial showed.

Pearl Toh, 5 days ago
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.
Tristan Manalac, 2 days ago
People are more likely to follow social distancing measures for the novel coronavirus disease (COVID-19) pandemic when they thought that their friends and family did the same, too, according to a new study.

Faecal-to-oral SARS-CoV-2 transmission probable

17 Oct 2020

A substantial proportion of COVID-19 patients shed SARS-CoV-2 viral RNA in faeces, with the virus persisting long after respiratory testing has become negative, according to the results of a meta-analysis. This suggests that the disease can be spread via the faecal–oral route.

Researchers conducted a systematic review of studies and retrieved 95 studies to critically assess performance and accuracy of testing stool samples or anal swabs in relation to the potential of orofaecal transmission of SARS‐CoV‐2.

The majority of the included studies were performed in China (n=74), while other studies were conducted in Korea (n=6), Singapore (n=2), US (n=5), Italy (n=4), France (n=1), Germany (n=1), Thailand (n=1), and Austria (n=1). Seventeen studies tested SARS‐CoV‐2 presence in anal swabs and 81 in stool samples; both specimens were tested in three studies.

Real‐time reverse transcription polymerase chain reaction (RT‐PCR) was used to detect SARS‐CoV‐2 in nearly all studies, whereas one study performed inoculation of stool suspension into Vero cells followed by virus detection through electron microscopy.

Out of the 2,149 patients overall, 934 (43 percent) tested positive for SARS‐CoV‐2 in stool samples or anal swabs. Some of the tests that returned positive were conducted as late as 70 days after symptom onset.

A meta‐analysis including studies with 10 patients revealed a pooled positive proportion of 51.8 percent (95 percent confidence interval, 43.8–59.7).

Positive faecal samples from 282 out of 443 patients (64 percent) remained positive for SARS‐CoV‐2 for a mean of 12.5 days (33 days maximum) after respiratory samples became negative for viral RNA.

SARS‐CoV‐2 viability was detected in five studies, in which six patients (6/17, 35 percent) had live active virus in their gastrointestinal specimens using Vero cell testing.

In light of the findings, the researchers urged that stool sample or anal swab testing be reconsidered in relation to decisions for isolating or discharging a patient.

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Most Read Articles
Natalia Reoutova, 2 days ago

Patients with coronavirus disease 2019 (COVID-19) who have haematologic malignancies have a 28 percent mortality rate, according to data collected from 250 patients by the ASH Research Collaborative COVID-19 presented at the 62nd American Society of Hematology Annual Meeting and Exposition (ASH 2020).

Roshini Claire Anthony, 01 Dec 2020

An evidence-based, multifaceted intervention aimed at reducing haemodialysis catheter-related bloodstream infections (HD-CRBSIs) failed to improve this outcome, results of the REDUCCTION* trial showed.

Pearl Toh, 5 days ago
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.
Tristan Manalac, 2 days ago
People are more likely to follow social distancing measures for the novel coronavirus disease (COVID-19) pandemic when they thought that their friends and family did the same, too, according to a new study.