Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
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Faecal microbiota transplantation safe, effective for treating CDI in kids, young adults

20 Mar 2020

Faecal microbiota transplantation (FMT) may be performed in children and young adults to treat Clostridium difficile infection (CDI), with a study showing that the procedure is safe and effective and may be considered earlier in the disease course.

Researchers reviewed the medical records of 335 CDI patients aged 11 months to 23 years old, who were followed for at least 2 months following FMT. There were 120 patients with comorbid inflammatory bowel disease. Successful treatment was defined as the absence of recurrence throughout the follow-up.

A total of 271 patients (81 percent) achieved a successful outcome following FMT. Among the 64 patients who had CDI recurrence, 34 (53.1 percent) underwent repeat FMT, which was successful in 19 (55.9 percent). The overall success rate of one or two FMT procedures was 86.6 percent.

Factors associated with successful FMT included use of fresh donor stool (odds ratio [OR], 2.66, 95 percent confidence interval [CI], 1.39–5.08), delivery of FMT via colonoscopy (OR, 2.41, 95 percent CI, 1.26–4.61), nonrequirement of a feeding tube (OR, 2.08, 95 percent CI, 1.05–4.11), and having one lower total number of CDI episodes before FMT (OR, 1.20, 95 percent CI, 1.04–1.39).

Severe adverse events occurred in 17 patients (4.7 percent), including 10 hospitalizations. No deaths were recorded during the follow-up period.

The researchers called for additional investigation to determine the optimal timing and method of FMT for paediatric patients.

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Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Dr. Wong Soon Tee, 17 hours ago
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.