Most Read Articles
13 Sep 2020
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 3 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
5 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


Faecal microbiota transplantation provides long-term cure for recurrent CDI

15 Aug 2020

Most patients with recurrent Clostridioides difficile infection (rCDI) experience long-term cure after faecal microbiota transplantation (FMT), reports a study that claims to be the largest and longest investigation on the safety and efficacy of FMT for rCDI treatment.

“Although a number of new conditions developed post-FMT, there was no clustering of diseases associated with dysbiosis,” the researchers said.

To examine the long-term efficacy and safety of FMT for the treatment of rCDI, a multicentre retrospective study was conducted on patients with rCDI who were unresponsive to standard medical therapy. Participants were treated with FMT with ≥6 months of clinical follow-up after the procedure.

The researchers contacted the patients to document sustained efficacy, potential adverse events, and antibiotic exposure. Then, they reviewed the electronic medical record to confirm patient-reported outcomes and obtain additional data. Sustained cure, defined as the absence of CDI at any timepoint after FMT, was the primary outcome.

A total of 528 patients received FMT, but only 207 were successfully contacted over a mean follow-up of 34 months (range, 6–84 months) post-FMT. Fifty-two (9.8 percent) had died at the time of follow-up contact, but none were considered FMT-related. Of the 207 patients, 157 (75.8 percent) reported sustained cure at the time of follow-up.

Use of antibiotics for non-CDI indications post-FMT was reported by 100 patients (48 percent), of whom 11 (11 percent) had experienced CDI after the procedure. Nearly half of the patients (n=105; 50.5 percent) reported new medical conditions or diagnoses post-FMT, and 15 reported improvement in previously diagnosed medical conditions following FMT.

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Most Read Articles
13 Sep 2020
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 3 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
5 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.